Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211633 | 0.97 | MAOB (0.55) | MAOBOPRM1LMNACYP1A2PTGS1 | |
| SCHEMBL6208936 | 0.96 | MAOB (0.54) | MAOBOPRM1LMNACYP1A2PTGS1 | |
| SCHEMBL6208176 | 0.94 | MAOB (0.58) | MAOBOPRM1LMNACYP1A2PTGS1 | |
| SCHEMBL21874085 | 0.87 | MAOB (0.51) | MAOBOPRM1LMNACYP1A2PTGS1 | |
| SCHEMBL9966478 | 0.87 | MAOB (0.51) | MAOBOPRM1LMNACYP1A2PTGS1 | |
| SCHEMBL11044387 | 0.86 | MAOB (0.50) | MAOBOPRM1LMNACYP1A2PTGS1 | |
| SCHEMBL2274605 | 0.86 | LMNA (0.51) | MAOBLMNASMN1; SMN2FFAR4MAPT | |
| SCHEMBL624010 | 0.80 | OPRM1 (0.54) | OPRM1LMNASMN1; SMN2RAB9A | |
| SCHEMBL624584 | 0.80 | KMT2A (0.48) | OPRM1LMNASMN1; SMN2MAPTRAB9A | |
| SCHEMBL16553890 | 0.77 | LMNA (0.56) | MAOBLMNACYP1A2PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066329-B1 | SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF CYCLOBUTYLMETHYLAMINES | REVIVA PHARMACEUTICALS INC (US) | 2017-09-06 | — | — | EP | disclosed |
| US-9302981-B2 | Synthesis, methods of using, and compositions of cycloalkylmethylamines | REVIVA PHARMACEUTICALS, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20140194508-A1 | SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF CYCLOALKYLMETHYLAMINES | REVIVA PHARMACEUTICALS, INC. (US) | 2014-07-10 | — | — | US | disclosed |
| US-8669285-B2 | Synthesis, methods of using, and compositions of cycloalkylmethylamines | REVIVA PHARMACEUTICALS, INC. (US) | 2014-03-11 | — | — | US | disclosed |
| US-20130231386-A1 | SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF CYCLOALKYLMETHYLAMINES | REVIVA PHARMACEUTICALS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-8445714-B2 | Cycloalkylmethylamines | REVIVA PHARMACEUTICALS, INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-8372883-B2 | Methods of using cycloalkylmethylamines | REVIVA PHARMACEUTICALS, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-8338632-B2 | Cycloalkylmethylamines | REVIVA PHARMACEUTICALS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20110263704-A1 | Methods of Using Cycloalkylmethylamines | REVIVA PHARMACEUTICALS, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263888-A1 | Cycloalkylmethylamines | REVIVA PHARMACEUTICALS, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263877-A1 | Cycloalkylmethylamines | REVIVA PHARMACEUTICALS, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-7989500-B2 | Synthesis, methods of using, and compositions of cycloalkylmethylamines | REVIVA PHARMACEUTICALS, INC. (US) | 2011-08-02 | — | — | US | disclosed |
| EP-2066329-A2 | SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF CYCLOALKYLMETHYLAMINES | Reviva Pharmaceuticals, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| US-20080139663-A1 | Cycloalkylmethylamine analogs; use treating obesity or related co-morbid indications | REVIVA PHARMACEUTICALS, INC. | 2008-06-12 | — | — | US | disclosed |
| WO-2008034142-A2 | SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF CYCLOALKYLMETHYLAMINES | REVIVA PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | BAYER HEALTHCARE AG (DE) | 2005-10-20 | — | — | US | disclosed |
| EP-1507763-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | Bayer HealthCare AG (DE) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097607-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263704-A1 | Methods of Using Cycloalkylmethylamines | AADAC, PNMT, INMT | MAOB 141/4885OPRM1 100/4885LMNA 3042/4885 |
| US-20110263888-A1 | Cycloalkylmethylamines | AADAC, GPR119, INMT | MAOB 185/4885OPRM1 54/4885LMNA 3131/4885 |
| US-20140194508-A1 | SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF CYCLOALKYLMETHYLAMINES | AADAC, INMT, AADAT | MAOB 171/4885OPRM1 120/4885LMNA 2928/4885 |
| US-20080139663-A1 | Cycloalkylmethylamine analogs; use treating obesity or related co-morbid indications | AADAC, GPR119, MC4R | MAOB 183/4885OPRM1 13/4885LMNA 3837/4885 |
| US-20110263877-A1 | Cycloalkylmethylamines | AADAC, GPR119, INMT | MAOB 185/4885OPRM1 54/4885LMNA 3131/4885 |
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | PPARD, PPARG, PPARA | MAOB 3628/4885OPRM1 2605/4885LMNA 2034/4885 |
| US-20130231386-A1 | SYNTHESIS, METHODS OF USING, AND COMPOSITIONS OF CYCLOALKYLMETHYLAMINES | AADAC, INMT, AADAT | MAOB 171/4885OPRM1 120/4885LMNA 2928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.