SCHEMBL22772415

SCHEMBL22772415

[CH2][CH][Si]([CH][CH2])(c1ccccc1)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.35
TSHR P16473 1/20 0.35
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
KDM4E B2RXH2 1/20 0.30
HPGD P15428 1/20 0.30
AKR1C1 Q04828 1/20 0.30
TGM2 P21980 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL160241 0.77 ALDH1A1 (0.41) ALDH1A1TSHRESR1ESR2TGM2
SCHEMBL9418213 0.69 TSHR (0.35) ALDH1A1TSHRTGM2
SCHEMBL9418211 0.69 TSHR (0.35) ALDH1A1TSHRTGM2
SCHEMBL11024215 0.69 ALDH1A1 (0.36) ALDH1A1TSHRMEN1KMT2ATGM2
SCHEMBL8002913 0.67 ALDH1A1 (0.32) ALDH1A1TSHRESR1ESR2
SCHEMBL28638586 0.67 MAPT (0.35) TSHRESR1ESR2
SCHEMBL439491 0.65 ESR1 (0.36) ALDH1A1TSHRMEN1KMT2AESR1
SCHEMBL49539 0.65 TSHR (0.39) ALDH1A1TSHRMEN1KMT2AESR1
SCHEMBL226240 0.65 ALDH1A1 (0.41) ALDH1A1TSHRMEN1KMT2AESR1
SCHEMBL1674781 0.65 ALDH1A1 (0.41) ALDH1A1TSHRESR1ESR2TGM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3983461-A1 SILYL-CONTAINING ACRYLATES AND DEGRADABLE RADICAL-CURED NETWORKS THEREOF The Government of the United States of America, as represented by the Secretary of the Navy (US) 2022-04-20 EP disclosed
WO-2020252489-A1 SILYL-CONTAINING ACRYLATES AND DEGRADABLE RADICAL-CURED NETWORKS THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2020-12-17 WO disclosed
US-20200392273-A1 SILYL-CONTAINING ACRYLATES AND DEGRADABLE RADICAL-CURED NETWORKS THEREOF THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2020-12-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200392273-A1 SILYL-CONTAINING ACRYLATES AND DEGRADABLE RADICAL-CURED NETWORKS THEREOF LSM14A, MGMT, AS3MT ALDH1A1 263/4885TSHR 3117/4885MEN1 1270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.