SCHEMBL439491

SCHEMBL439491

[CH2][Si](c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
ALDH1A1 P00352 6/20 0.35
TSHR P16473 5/20 0.33
RAB9A P51151 2/20 0.33
NPC1 O15118 1/20 0.33
MAPK1 P28482 1/20 0.33
NOTUM Q6P988 1/20 0.32
TDP1 Q9NUW8 4/20 0.32
CA1 P00915 2/20 0.32
CA2 P00918 2/20 0.32
CA9 Q16790 2/20 0.32
MAPT P10636 2/20 0.32
CA12 O43570 1/20 0.32
GLA P06280 1/20 0.32
CA3 P07451 1/20 0.32
CA4 P22748 1/20 0.32
CA14 Q9ULX7 1/20 0.32
LMNA P02545 1/20 0.32
ALOX12 P18054 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28593264 0.97 ESR1 (0.35) ESR1ESR2ALDH1A1TSHRRAB9A
SCHEMBL9339604 0.73 ESR1 (0.44) ESR1ESR2ALDH1A1TSHRRAB9A
SCHEMBL852151 0.73 ESR1 (0.44) ESR1ESR2ALDH1A1TSHRRAB9A
SCHEMBL464991 0.69 ALDH1A1 (0.40) ESR1ESR2ALDH1A1TSHRRAB9A
SCHEMBL242095 0.69 ALDH1A1 (0.40) ESR1ESR2ALDH1A1TSHRRAB9A
SCHEMBL21693937 0.67 TP53 (0.38) ESR1ESR2ALDH1A1TSHRMAPT
Ethylene SCHEMBL25342007 0.67 ESR1 (0.44) ESR1ESR2ALDH1A1TSHRRAB9A
SCHEMBL2144485 0.67 MAPT (0.50) ESR1ESR2ALDH1A1RAB9ANPC1
SCHEMBL434194 0.67 ESR1 (0.44) ESR1ESR2ALDH1A1TSHRRAB9A
SCHEMBL103830 0.67 ESR1 (0.43) ESR1ESR2ALDH1A1TSHRRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 166 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210121863-A1 Catalyst Systems Including Salan Catalyst and Non-Coordinating Anion Type Activator Containing Cation Having Alkyl Groups and uses Thereof EXXONMOBIL CHEMICAL PATENTS INC. 2021-04-29 US claimed
CN-109705063-B Entecavir intermediate and synthetic method thereof, and synthetic method of entecavir 广州市朗启医药科技有限责任公司 2021-01-01 CN claimed
CN-115028766-B Supported catalyst systems and methods of use thereof 埃克森美孚化学专利公司 2024-06-28 CN disclosed
CN-117304374-A Olefin polymerization metallocene catalyst composition, and preparation and application thereof 中国石油天然气股份有限公司 2023-12-29 CN disclosed
WO-2023246009-A1 OLEFIN POLYMERIZATION METALLOCENE CATALYST COMPOSITION, PREPARATION THEREOF AND USE THEREOF 中国石油天然气股份有限公司 2023-12-28 WO disclosed
CN-117285668-A Ethylene-propylene copolymer catalyst composition and preparation and application thereof 中国石油天然气股份有限公司 2023-12-26 CN disclosed
WO-2023240961-A1 ETHYLENE-PROPYLENE COPOLYMERIZATION CATALYST COMPOSITION, AND PREPARATION AND USE THEREOF 中国石油天然气股份有限公司 2023-12-21 WO disclosed
CN-110088149-B Supported catalyst systems and methods of use thereof 埃克森美孚化学专利公司 2023-10-27 CN disclosed
EP-3604362-B1 MULTI-COMPONENT POLAR OLEFIN COPOLYMER AND METHOD FOR PRODUCING SAME JAPAN POLYETHYLENE CORP (JP) 2023-08-02 EP disclosed
US-20230132484-A1 STERICALLY HINDERED PHOSPHINE-AMIDE SUPPORTED NICKEL (II) OR PALLADIUM (II) CATALYSTS FOR THE COPOLYMERIZATION OF ETHYLENE AND POLAR COMONOMERS DOW GLOBAL TECHNOLOGIES LLC (US) 2023-05-04 US disclosed
US-20230129371-A1 STERICALLY HINDERED PHOSPHINO-UREA SUPPORTED NICKEL (II) OR PALLADIUM (II) CATALYSTS FOR THE COPOLYMERIZATION OF ETHYLENE AND POLAR COMONOMERS DOW GLOBAL TECHNOLOGIES LLC (US) 2023-04-27 US disclosed
WO-2009104782-A1 ETHYLENE HOMOPOLYMER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-08-27 WO disclosed
WO-2009104783-A1 CATALYST COMPONENT FOR POLYMERIZATION OF ETHYLENE AND PROCESS FOR PRODUCING ETHYLENE POLYMER (2) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-08-27 WO disclosed
US-20090137755-A1 ETHYLENE POLYMER, CATALYST FOR ETHYLENE POLYMER PRODUCTION, AND METHOD FOR PRODUCING ETHYLENE POLYMER TOSOH CORPORATION (JP) 2009-05-28 US disclosed
EP-1964860-A1 ETHYLENE POLYMER, CATALYST FOR PRODUCTION OF ETHYLENE POLYMER, AND PROCESS FOR PRODUCTION OF ETHYLENE POLYMER Tosoh Corporation (JP) 2008-09-03 EP disclosed
EP-1473323-A1 Polyethylene composition and process for producing same Tosoh Corporation (JP) 2004-11-03 EP disclosed
US-20040214953-A1 Polyethylene composition and process for producing same TOSOH CORPORATION 2004-10-28 US disclosed
EP-0802243-B1 Coating composition NOF CORP (JP) 2001-06-27 EP disclosed
US-5795374-A SILYL ACRYLATE POLYMERS NOF CORPORATION (JP) 1998-08-18 US disclosed
EP-0802243-A2 Coating composition NOF CORPORATION (JP) 1997-10-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230129371-A1 STERICALLY HINDERED PHOSPHINO-UREA SUPPORTED NICKEL (II) OR PALLADIUM (II) CATALYSTS FOR THE COPOLYMERIZATION OF ETHYLENE AND POLAR COMONOMERS PCNA, NIT2, MCM7 ESR1 321/4885ESR2 676/4885ALDH1A1 2942/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.