Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17513282 | 0.82 | MEN1 (1.00) | MEN1KMT2AL3MBTL1MAPTMAP2K1 | |
| SCHEMBL5399245 | 0.82 | MEN1 (0.50) | MEN1KMT2AL3MBTL1MAPTMAP2K1 | |
| SCHEMBL3722673 | 0.79 | MEN1 (0.47) | MEN1KMT2AL3MBTL1MAPTMAP2K1 | |
| SCHEMBL9037964 | 0.79 | KMT2A (0.70) | MEN1KMT2AL3MBTL1MAPTMAP2K1 | |
| SCHEMBL8188963 | 0.77 | ACHE (0.47) | MEN1KMT2AL3MBTL1MAPTMAP2K1 | |
| SCHEMBL8188585 | 0.76 | MEN1 (0.70) | MEN1KMT2AL3MBTL1MAPTMAP2K1 | |
| SCHEMBL9035160 | 0.74 | KMT2A (0.62) | MEN1KMT2AL3MBTL1MAPTMAPK1 | |
| SCHEMBL7666502 | 0.73 | MEN1 (0.60) | MEN1KMT2AL3MBTL1MAPTMAP2K1 | |
| SCHEMBL24886285 | 0.72 | PARP10 (0.56) | MEN1KMT2AL3MBTL1MAP2K1RAF1 | |
| SCHEMBL3715989 | 0.71 | MAPT (0.64) | MEN1KMT2AL3MBTL1MAPTMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094714-B1 | SUBSTITUTED THIENOPYRIDONE COMPOUNDS WITH ANTIBACTERIAL ACTIVITY | CRESTONE INC (US) | 2012-08-15 | — | — | EP | disclosed |
| US-7994192-B2 | 5-[3-(6,8-Dibromo-1,2,3,4-tetrahydro-quinolin-4-ylamino)-propylamino]-4H-thieno [3,2-b]pyridin-7-one, used as inhibitors of bacterial methionyl tRNA synthetase, administered for the treatment of bacterial infections; therapy for Clostridium difficile based infections | CRESTONE, INC. (US) | 2011-08-09 | — | — | US | disclosed |
| EP-2094714-A2 | SUBSTITUTED THIENOPYRIDONE COMPOUNDS WITH ANTIBACTERIAL ACTIVITY | Crestone, Inc. (US) | 2009-09-02 | — | — | EP | disclosed |
| US-20080146609-A1 | Substituted Thienopyridone Compounds With Antibacterial Activity | REPLIDYNE, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| WO-2008039639-A2 | SUBSTITUTED THIENOPYRIDONE COMPOUNDS WITH ANTIBACTERIAL ACTIVITY | CRESTONE, INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| WO-2000021949-A1 | QUINOLONES AS T-RNA SYNTHETASE INHIBITORS AND ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2000-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146609-A1 | Substituted Thienopyridone Compounds With Antibacterial Activity | TRDMT1, TYMS, WARS1 | MEN1 2890/4885KMT2A 1169/4885L3MBTL1 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.