Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.51 |
| ▸ | TFEB | P19484 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Isopropyl-3-Methoxycinnamic Acid SCHEMBL2280935 | 1.00 | KDM4E (1.00) | KDM4EGAANFE2L2TFEBLMNA | |
| SCHEMBL5179255 | 0.86 | KDM4E (0.76) | KDM4EGAANFE2L2TFEBLMNA | |
| Coumarinic Acid Methyl Ether SCHEMBL22092089 | 0.81 | KDM4E (0.68) | KDM4EGAANFE2L2TFEBLMNA | |
| SCHEMBL9689786 | 0.81 | KDM4E (0.68) | KDM4EGAANFE2L2TFEBLMNA | |
| SCHEMBL16831490 | 0.81 | KDM4E (0.68) | KDM4EGAANFE2L2TFEBLMNA | |
| Coumarinic Acid Methyl Ether SCHEMBL83064 | 0.80 | NFE2L2 (0.77) | KDM4EGAANFE2L2TFEBLMNA | |
| Coumarinic Acid Methyl Ether SCHEMBL29369917 | 0.80 | NFE2L2 (0.77) | KDM4EGAANFE2L2TFEBLMNA | |
| Coumarinic Acid Methyl Ether SCHEMBL79060 | 0.80 | NFE2L2 (0.77) | KDM4EGAANFE2L2TFEBLMNA | |
| Coumarinic Acid Methyl Ether SCHEMBL714857 | 0.80 | NFE2L2 (0.77) | KDM4EGAANFE2L2TFEBLMNA | |
| SCHEMBL1056670 | 0.80 | NFE2L2 (0.79) | KDM4EGAANFE2L2TFEBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110189310-A1 | SMALL MOLECULE MODULATORS OF PRONGF UPTAKE | CORNELL UNIVERSITY (US) | 2011-08-04 | — | — | US | claimed |
| WO-2010042728-A1 | SMALL MOLECULE MODULATORS OF PRONGF UPTAKE | CORNELL UNIVERSITY (US) | 2010-04-15 | — | — | WO | claimed |
| US-20110189310-A1 | SMALL MOLECULE MODULATORS OF PRONGF UPTAKE | CORNELL UNIVERSITY (US) | 2011-08-04 | — | — | US | disclosed |
| WO-2010042728-A1 | SMALL MOLECULE MODULATORS OF PRONGF UPTAKE | CORNELL UNIVERSITY (US) | 2010-04-15 | — | — | WO | disclosed |
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PC, PCK2, CS | KDM4E 3739/4885GAA 91/4885NFE2L2 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.