Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093089 | 0.90 | HDAC1 (0.58) | SIGMAR1NPC1HRH3HPGDSMN1; SMN2 | |
| SCHEMBL8326447 | 0.89 | SIGMAR1 (0.66) | SIGMAR1HRH3FKBP1AKDM4EALDH1A1 | |
| SCHEMBL8324239 | 0.88 | FKBP1A (0.72) | SIGMAR1FKBP1AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL13624853 | 0.88 | SIGMAR1 (0.61) | SIGMAR1HRH3PARP1FKBP1AKDM4E | |
| SCHEMBL2835539 | 0.88 | KMT2A (0.60) | SIGMAR1NPC1TDP1HRH3KDM4E | |
| SCHEMBL14218060 | 0.87 | SIGMAR1 (0.67) | SIGMAR1HRH3PARP1KDM4EALDH1A1 | |
| SCHEMBL4378416 | 0.85 | ALDH1A1 (0.73) | SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL4376335 | 0.84 | ALDH1A1 (0.76) | SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL23009037 | 0.83 | ME2 (0.68) | SIGMAR1NPC1KDM4EL3MBTL1 | |
| SCHEMBL4377878 | 0.83 | SIGMAR1 (0.61) | SIGMAR1NPC1HRH3PARP1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3253734-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV MICHIGAN REGENTS (US) | 2020-12-23 | — | — | EP | disclosed |