Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 4/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | PCNA | P12004 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22813680 | 0.88 | SIGMAR1 (0.62) | FKBP1AL3MBTL1SIGMAR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8326447 | 0.86 | SIGMAR1 (0.66) | FKBP1ASIGMAR1GAAALDH1A1MEN1 | |
| SCHEMBL13624853 | 0.85 | SIGMAR1 (0.61) | FKBP1ASIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL14218060 | 0.84 | SIGMAR1 (0.67) | L3MBTL1SIGMAR1GAAALDH1A1MEN1 | |
| SCHEMBL23009037 | 0.82 | ME2 (0.68) | L3MBTL1SIGMAR1GAAPOLBMEN1 | |
| SCHEMBL4378642 | 0.81 | L3MBTL1 (0.57) | L3MBTL1SIGMAR1GAAPOLBALDH1A1 | |
| SCHEMBL3442081 | 0.80 | FKBP1A (0.69) | FKBP1APOLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4377878 | 0.80 | SIGMAR1 (0.61) | FKBP1ASIGMAR1GAARAB9AALDH1A1 | |
| SCHEMBL2835539 | 0.80 | KMT2A (0.60) | SIGMAR1POLBALDH1A1MEN1KMT2A | |
| SCHEMBL4378416 | 0.80 | ALDH1A1 (0.73) | SIGMAR1POLBRAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |