Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | IDO1 | P14902 | 2/20 | 0.62 |
| ▸ | ALPL | P05186 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TTK | P33981 | 1/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15878687 | 0.84 | ROCK1 (0.72) | LMNAROCK2ROCK1 | |
| Propionic Acid SCHEMBL4552403 | 0.81 | KDM4E (0.71) | MAP2K4GAAKDM4EALDH1A1IDO1 | |
| SCHEMBL3732433 | 0.80 | MAP2K4 (1.00) | MAP2K4GAAKDM4EALDH1A1IDO1 | |
| SCHEMBL31369711 | 0.79 | MAP2K4 (0.58) | MAP2K4GAAKDM4EALDH1A1IDO1 | |
| SCHEMBL9951780 | 0.79 | GRM4 (0.45) | MAP2K4GAAKDM4EALDH1A1IDO1 | |
| SCHEMBL17178615 | 0.78 | ALDH1A1 (0.92) | MAP2K4GAAKDM4EALDH1A1IDO1 | |
| SCHEMBL30768403 | 0.78 | ALDH1A1 (1.00) | MAP2K4GAAKDM4EALDH1A1IDO1 | |
| SCHEMBL855531 | 0.78 | ALDH1A1 (1.00) | MAP2K4GAAKDM4EALDH1A1IDO1 | |
| SCHEMBL27688197 | 0.78 | IDO1 (0.65) | MAP2K4GAAKDM4EALDH1A1IDO1 | |
| SCHEMBL462088 | 0.76 | LMNA (0.68) | MAP2K4GAAKDM4EALDH1A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370770-B2 | 3-arylindazoles as selective MEK4 inhibitors | NORTHWESTERN UNIVERSITY (US) | 2022-06-28 | — | — | US | disclosed |
| US-20200399241-A1 | 3-ARYLINDAZOLES AS SELECTIVE MEK4 INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399241-A1 | 3-ARYLINDAZOLES AS SELECTIVE MEK4 INHIBITORS | MAP4K3, MAPK4, MAP3K4 | MAP2K4 39/4885GAA 3203/4885KDM4E 788/4885 |
| US-11370770-B2 | 3-arylindazoles as selective MEK4 inhibitors | MAP4K3, MAPK4, MAP3K4 | MAP2K4 39/4885GAA 3203/4885KDM4E 788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.