Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22820711 | 0.87 | NR1H2 (0.35) | PIK3CDNR1H2NR1H3CCR2AAK1 | |
| SCHEMBL22820577 | 0.85 | USP30 (0.46) | POLBNR1H2NR1H3AAK1USP30 | |
| SCHEMBL29914412 | 0.85 | USP30 (0.46) | POLBNR1H2NR1H3AAK1USP30 | |
| SCHEMBL31401133 | 0.83 | CYP1A2 (0.52) | PIK3CDCYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL22820517 | 0.83 | AAK1 (0.37) | PIK3CDNR1H2NR1H3CCR2AAK1 | |
| SCHEMBL22820604 | 0.80 | CCR2 (0.37) | NR1H2NR1H3CCR2AAK1USP30 | |
| SCHEMBL23064594 | 0.78 | RIPK1 (0.43) | PIK3CDCYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL22820710 | 0.78 | AAK1 (0.34) | AAK1SMN1; SMN2 | |
| SCHEMBL25847099 | 0.76 | CYP1A2 (0.37) | PIK3CDCYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL31316866 | 0.76 | NR1H2 (0.49) | PIK3CDCYP1A2POLBCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220177458-A1 | HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-09 | — | — | US | disclosed |
| WO-2020255022-A1 | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND AMINOPYRIDINE DERIVATIVES AS HPK1 INHIBITORS | Janssen Sciences Ireland Unlimited Company (IE) | 2020-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220177458-A1 | HPK1 INHIBITORS | PGK1, PCK1, PDXK | PIK3CD 1287/4885CYP1A2 3766/4885POLB 1924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.