Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 6/20 | 0.69 |
| ▸ | KDM1A | O60341 | 1/20 | 0.58 |
| ▸ | TDP2 | O95551 | 2/20 | 0.57 |
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13297258 | 0.82 | GRIA2 (1.00) | GRIA2CYP1A2CYP2C19KCNH2 | |
| SCHEMBL13297274 | 0.78 | BRD4 (0.50) | GRIA2BRD4CREBBP | |
| SCHEMBL21092440 | 0.77 | KIF11 (0.69) | KDM1ATDP2KIF11BRD4LMNA | |
| SCHEMBL25964972 | 0.77 | KDM1A (0.69) | GRIA2KDM1ATDP2KIF11BRD4 | |
| SCHEMBL7179130 | 0.76 | KIF11 (0.68) | GRIA2KDM1ATDP2KIF11BRD4 | |
| SCHEMBL13297281 | 0.75 | GRIA2 (0.47) | GRIA2KDM1ATDP2BRD4CYP1A2 | |
| SCHEMBL7179126 | 0.75 | KIF11 (0.66) | GRIA2KDM1ATDP2KIF11BRD4 | |
| SCHEMBL13297283 | 0.75 | CA2 (0.51) | GRIA2CREBBP | |
| SCHEMBL1091569 | 0.74 | TDP2 (0.61) | GRIA2KDM1ATDP2KIF11BRD4 | |
| SCHEMBL13297285 | 0.73 | GRIA2 (0.67) | GRIA2MAPK1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200397751-A1 | Modulation of AMPA/kainate Receptors for the Treatment of Hypoglycemia | VANDERKLISH PETER (US) | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200397751-A1 | Modulation of AMPA/kainate Receptors for the Treatment of Hypoglycemia | GPR119, GRIK1, GRIK3 | GRIA2 60/4885KDM1A 1428/4885TDP2 3640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.