Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16053764 | 0.91 | L3MBTL1 (0.48) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL22864682 | 0.90 | L3MBTL1 (0.49) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL30751751 | 0.87 | L3MBTL1 (0.49) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL6356789 | 0.86 | CYP2D6 (0.46) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL4509900 | 0.85 | ALDH1A1 (0.50) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL30751712 | 0.80 | SIGMAR1 (0.48) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL27329178 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1L3MBTL1ATM | |
| SCHEMBL31516363 | 0.77 | CYP2D6 (0.51) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL4509125 | 0.76 | ALDH1A1 (0.53) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL21685887 | 0.76 | SIGMAR1 (0.47) | ALDH1A1LMNAKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2022-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | HIPK1, SIK1, PGK1 | ALDH1A1 3740/4885LMNA 3287/4885KMT2A 2256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.