SCHEMBL2287366

SCHEMBL2287366

Nc1nc(NC2O[C@H](C(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(N)c(=O)[nH]1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 1/20 0.32
NT5E P21589 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2292031 0.81
SCHEMBL2935421 0.77 EIF4E (0.45) HPRT1NT5E
SCHEMBL29453202 0.77 EIF4E (0.45) HPRT1NT5E
SCHEMBL3236739 0.72 GSK3B (0.53)
SCHEMBL9848321 0.71 MEN1 (0.30)
SCHEMBL3134528 0.69 PAX8 (0.33)
SCHEMBL5861503 0.69 NT5E (0.60) NT5E
SCHEMBL4081026 0.69 NT5E (0.60) NT5E
SCHEMBL16098965 0.69 RAB9A (0.38)
SCHEMBL16008962 0.69 RAB9A (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051504-A2 RIBOFLAVIN BIOSYNTHESIS GENES FROM PLANTS AND USES THEREOF Novartis AG (CH) 2000-11-15 EP claimed
WO-1999038986-A2 RIBOFLAVIN BIOSYNTHESIS GENES FROM PLANTS AND USES THEREOF NOVARTIS AG (CH) 1999-08-05 WO claimed
US-20230235375-A1 FERMENTATION PROCESS DSM IP ASSETS B.V. (NL) 2023-07-27 US disclosed
EP-4168565-A2 FERMENTATION PROCESS DSM IP Assets B.V. (NL) 2023-04-26 EP disclosed
CN-115715328-A Fermentation process 帝斯曼知识产权资产管理有限公司 2023-02-24 CN disclosed
US-20220010291-A1 IMPROVED PRODUCTION OF RIBOFLAVIN DSM IP ASSETS B.V. (NL) 2022-01-13 US disclosed
WO-2021260057-A2 FERMENTATION PROCESS DSM IP ASSETS B.V. (NL) 2021-12-30 WO disclosed
EP-3880835-A1 IMPROVED PRODUCTION OF RIBOFLAVIN DSM IP Assets B.V. (NL) 2021-09-22 EP disclosed
CN-113015811-A Improved riboflavin production 帝斯曼知识产权资产管理有限公司 2021-06-22 CN disclosed
WO-2020099303-A1 IMPROVED PRODUCTION OF RIBOFLAVIN DSM IP ASSETS B.V. (NL) 2020-05-22 WO disclosed
EP-1814983-B1 IMPROVED ENZYMES DSM IP ASSETS BV (NL) 2013-08-21 EP disclosed
US-6551813-B1 Yeast extract, glucose, a magnesium salt, a manganese salt, a calcium salt, an iron salt, a phosphate buffer, and additional salt selected from the group consisting of a glutamic acid salt, a citric acid salt, and a succinic acid salt ROCHE VITAMINS INC. 2003-04-22 US disclosed
US-6322995-B1 RECOMBINANT GRAM POSITIVE BACTERIUM USED FOR PRODUCING RIBOFLAVIN F. HOFFMANN-LA ROCHE AG (CH) 2001-11-27 US disclosed
EP-1051504-A2 RIBOFLAVIN BIOSYNTHESIS GENES FROM PLANTS AND USES THEREOF Novartis AG (CH) 2000-11-15 EP disclosed
EP-0405370-B1 Riboflavinoverproducing strains of bacteria HOFFMANN LA ROCHE (CH) 2000-08-30 EP disclosed
EP-1001026-A2 Riboflavinoverproducing strains of bacteria F. Hoffmann-La Roche AG (CH) 2000-05-17 EP disclosed
WO-1999038986-A2 RIBOFLAVIN BIOSYNTHESIS GENES FROM PLANTS AND USES THEREOF NOVARTIS AG (CH) 1999-08-05 WO disclosed
US-5925538-A CULTURING RECOMBINANT BACTERIUM HAVING EXOGENOUS NUCLEIC ACID SEQUENCE CODING FOR PROMOTER AND OPEN READING FRAME 3 STRUCTURAL GENE SIMILAR TO A BACILLUS SUBTILIS RIBOFLAVIN OPERON GENE, RECOVERING AT LEAST 10 GRAMS PER LITER ROCHE VITAMINS INC. (US) 1999-07-20 US disclosed
US-5837528-A NUCLEOTIDE SEQUENCE OF RIB OPERON AND ITS OPEN READING FRAMES; GENETIC ENGINEERING HOFFMANN LA ROCHE, INC. (US) 1998-11-17 US disclosed
EP-0405370-A1 Riboflavinoverproducing strains of bacteria F. HOFFMANN-LA ROCHE AG (CH) 1991-01-02 EP disclosed