Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 7/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | CASP9 | P55211 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31513819 | 0.81 | AHR (0.51) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904362 | 0.80 | TDP2 (0.58) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904354 | 0.80 | TDP2 (0.58) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904286 | 0.78 | TDP2 (0.50) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904287 | 0.78 | TDP2 (0.50) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904296 | 0.75 | TDP2 (0.50) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL1122916 | 0.74 | CASP3 (0.49) | CASP3CASP7CASP6CASP8ALDH1A1 | |
| SCHEMBL27640476 | 0.74 | MAOA (0.52) | CASP7ALDH1A1L3MBTL1CYP3A4CYP2C19 | |
| SCHEMBL20886849 | 0.74 | TDP2 (0.64) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL8917078 | 0.72 | DRD2 (0.46) | CASP7ALDH1A1SMN1; SMN2NR1H2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |