Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904384 | 0.81 | DDB1 (0.43) | HSD17B10POLBNPSR1MEN1KMT2A | |
| SCHEMBL22904243 | 0.81 | NOTUM (0.42) | ACHEMGLLPOLBHPGDNPSR1 | |
| SCHEMBL22904387 | 0.81 | BPTF (0.50) | CYP3A4CYP2C9CYP2C19CYP2D6MEN1 | |
| SCHEMBL22904475 | 0.79 | TRIM24 (0.50) | ACHENPSR1MEN1KMT2AMAPK1 | |
| SCHEMBL22904481 | 0.76 | GPR119 (0.43) | AKR1C3POLBMEN1ALDH1A1 | |
| SCHEMBL22904386 | 0.76 | CHRNA7 (0.42) | HSP90AA1CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL22904388 | 0.75 | LTA4H (0.51) | MGLLMMP13HPGDNPSR1LMNA | |
| SCHEMBL22904474 | 0.74 | LIPE (0.46) | POLB | |
| SCHEMBL22904247 | 0.73 | ALDH1A1 (0.51) | MMP13LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL31465552 | 0.70 | KDM1A (0.40) | FAAHMGLLAKR1C3KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |