Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904384 | 0.81 | DDB1 (0.43) | MEN1KMT2ATDP1ALOX15ALDH1A1 | |
| SCHEMBL22904236 | 0.81 | ACHE (0.39) | MEN1KMT2ATSHRALOX15ALDH1A1 | |
| SCHEMBL22904387 | 0.81 | BPTF (0.50) | NOTUMMEN1KMT2ATDP1TSHR | |
| SCHEMBL22904475 | 0.79 | TRIM24 (0.50) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL22904474 | 0.77 | LIPE (0.46) | POLB | |
| SCHEMBL22904481 | 0.76 | GPR119 (0.43) | MEN1ALDH1A1POLB | |
| SCHEMBL22904386 | 0.76 | CHRNA7 (0.42) | MEN1KMT2AALDH1A1HTT | |
| SCHEMBL22904388 | 0.75 | LTA4H (0.51) | ALOX15ALDH1A1MAPK1LMNAHPGD | |
| SCHEMBL22904468 | 0.74 | P2RX7 (0.42) | MEN1KMT2AALDH1A1 | |
| SCHEMBL1238774 | 0.72 | ALDH1A1 (0.45) | NOTUMMEN1KMT2ATDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |