SCHEMBL22906276

SCHEMBL22906276

Cc1nn(C)c(=O)c(-c2c(F)ccc(Cl)c2CCc2ccc(-n3cncn3)cc2)c1OC(=O)C(C)C

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
HSP90AA1 P07900 1/20 0.33
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
S1PR1 P21453 1/20 0.31
S1PR3 Q99500 1/20 0.31
BRS3 P32247 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22085498 0.88 POLB (0.35) RAB9AMAPTHTTSMN1; SMN2
SCHEMBL24252100 0.87 SMN1; SMN2 (0.33) HTTSMN1; SMN2
SCHEMBL22031827 0.87 CYP1A2 (0.39) RXFP1HTTSMN1; SMN2
SCHEMBL22906243 0.86 RAB9A (0.35) RAB9ARXFP1HSP90AA1MAPTHTT
SCHEMBL30389030 0.84 HTR2A (0.31)
SCHEMBL30484557 0.84 CYP1A2 (0.36) SMN1; SMN2
SCHEMBL22085491 0.84 POLB (0.35) RAB9AMAPTHTT
SCHEMBL22031798 0.84 CYP1A2 (0.36) SMN1; SMN2
SCHEMBL22906269 0.83 CCR3 (0.33) MAPTHTTSMN1; SMN2
SCHEMBL22906296 0.83 MAPT (0.36) RAB9ARXFP1HSP90AA1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4371986-B1 SUBSTITUTED PYRIDAZINONES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2026-02-25 EP disclosed
US-12540120-B2 Herbicidal compounds SYNGENTA CROP PROTECTION AG (CH) 2026-02-03 US disclosed
CN-114555563-B Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-11-15 CN disclosed
EP-3999494-B1 SUBSTITUTED PYRIDAZINONES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2024-09-11 EP disclosed
CN-118108674-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-05-31 CN disclosed
CN-118084803-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-05-28 CN disclosed
EP-4371986-A2 SUBSTITUTED PYRIDAZINONES AS HERBICIDES Syngenta Crop Protection AG (CH) 2024-05-22 EP disclosed
EP-4357344-A2 SUBSTITUTED PYRIDAZINONES AS HERBICIDES Syngenta Crop Protection AG (CH) 2024-04-24 EP disclosed
US-20220281827-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-09-08 US disclosed
CN-114555563-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2022-05-27 CN disclosed
EP-3999494-A2 SUBSTITUTED PYRIDAZINONES AS HERBICIDES Syngenta Crop Protection AG (CH) 2022-05-25 EP disclosed
WO-2021009334-A2 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220281827-A1 HERBICIDAL COMPOUNDS DDT, HPD, PGD RAB9A 4008/4885RXFP1 3165/4885HSP90AA1 1661/4885
US-12540120-B2 Herbicidal compounds CBR3, CBR1, HACL2 RAB9A 3760/4885RXFP1 2585/4885HSP90AA1 861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.