SCHEMBL22906296

SCHEMBL22906296

Cc1nn(C)c(=O)c(-c2c(F)ccc(Cl)c2/C=C/c2ccc(-n3cncn3)cc2)c1OC(=O)C(C)C

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HSP90AA1 P07900 1/20 0.36
HTT P42858 1/20 0.36
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
RAB9A P51151 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
FBP1 P09467 1/20 0.32
F2 P00734 1/20 0.32
S1PR1 P21453 1/20 0.31
S1PR3 Q99500 1/20 0.31
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27200157 0.90 HSP90AA1 (0.30) MAPTSMN1; SMN2HSP90AA1HTT
SCHEMBL22031795 0.87 P2RX7 (0.33) SMN1; SMN2HTT
(Z)-1,2-Diphenylethene SCHEMBL29582372 0.84 TP53 (0.33) MAPTSMN1; SMN2KDM4EALDH1A1RAB9A
SCHEMBL29658200 0.83 P4HB (0.31) SMN1; SMN2
SCHEMBL27200156 0.83 P4HB (0.31) SMN1; SMN2
SCHEMBL22906276 0.83 RAB9A (0.33) MAPTSMN1; SMN2HSP90AA1HTTRAB9A
SCHEMBL22654069 0.83 FPR2 (0.31)
SCHEMBL29216938 0.81 SMN1; SMN2 (0.35) MAPTSMN1; SMN2HSP90AA1HTTKDM4E
SCHEMBL24661366 0.80 KEAP1 (0.30)
SCHEMBL22031783 0.80 PTGES (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4371986-B1 SUBSTITUTED PYRIDAZINONES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2026-02-25 EP disclosed
US-12540120-B2 Herbicidal compounds SYNGENTA CROP PROTECTION AG (CH) 2026-02-03 US disclosed
CN-114555563-B Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-11-15 CN disclosed
EP-3999494-B1 SUBSTITUTED PYRIDAZINONES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2024-09-11 EP disclosed
CN-118108674-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-05-31 CN disclosed
CN-118084803-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-05-28 CN disclosed
CN-118084802-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-05-28 CN disclosed
EP-4371986-A2 SUBSTITUTED PYRIDAZINONES AS HERBICIDES Syngenta Crop Protection AG (CH) 2024-05-22 EP disclosed
EP-4357344-A2 SUBSTITUTED PYRIDAZINONES AS HERBICIDES Syngenta Crop Protection AG (CH) 2024-04-24 EP disclosed
US-20220281827-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-09-08 US disclosed
EP-3999494-A2 SUBSTITUTED PYRIDAZINONES AS HERBICIDES Syngenta Crop Protection AG (CH) 2022-05-25 EP disclosed
WO-2021009334-A2 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220281827-A1 HERBICIDAL COMPOUNDS DDT, HPD, PGD MAPT 3439/4885SMN1; SMN2 4689/4885HSP90AA1 1661/4885
US-12540120-B2 Herbicidal compounds CBR3, CBR1, HACL2 MAPT 4774/4885SMN1; SMN2 4517/4885HSP90AA1 861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.