Known targets — ChEMBL curated mechanism
S1PR1S1PR2S1PR3S1PR4S1PR5rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetramethylammonium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.84 |
| ▸ | TSHR | P16473 | 2/20 | 0.84 |
| ▸ | GLA | P06280 | 1/20 | 0.84 |
| ▸ | HPGD | P15428 | 1/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.84 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.84 |
| ▸ | BLM | P54132 | 1/20 | 0.84 |
| ▸ | CA1 | P00915 | 10/20 | 0.55 |
| ▸ | CA2 | P00918 | 10/20 | 0.55 |
| ▸ | CA9 | Q16790 | 8/20 | 0.55 |
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | CA7 | P43166 | 3/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.55 |
| ▸ | CA3 | P07451 | 2/20 | 0.55 |
| ▸ | CA4 | P22748 | 2/20 | 0.55 |
| ▸ | CA6 | P23280 | 2/20 | 0.55 |
| ▸ | CA5A | P35218 | 2/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetramethylammonium Ion SCHEMBL589210 | 1.00 | RECQL (0.84) | RECQLTSHRGLAHPGDMAPK1 | |
| Tetramethylammonium Ion SCHEMBL1639322 | 1.00 | RECQL (0.84) | RECQLTSHRGLAHPGDMAPK1 | |
| Tetramethylammonium Ion SCHEMBL21633915 | 0.96 | RECQL (0.85) | RECQLTSHRGLAHPGDMAPK1 | |
| Tetramethylammonium Ion SCHEMBL28699181 | 0.96 | RECQL (0.85) | RECQLTSHRGLAHPGDMAPK1 | |
| Lithium Ion SCHEMBL25256858 | 0.91 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL22283886 | 0.91 | RECQL (0.91) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL22390647 | 0.91 | RECQL (1.00) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL23387500 | 0.91 | RECQL (1.00) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL22390632 | 0.91 | RECQL (1.00) | RECQLTSHRGLAHPGDMAPK1 | |
| SCHEMBL22390687 | 0.91 | RECQL (1.00) | RECQLTSHRGLAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858961-B2 | Solutions of quaternary and tertiary ammonium cation detergents to denature proteins, and kits for making them | AGILENT TECHNOLOGIES, INC. (US) | 2024-01-02 | — | — | US | claimed |
| CN-109714963-B | Use of quaternary ammonium cation and tertiary ammonium cation detergents in protein denaturation | 安捷伦科技有限公司 | 2022-08-09 | — | — | CN | claimed |
| US-20210371454-A1 | Solutions of Quaternary and Tertiary Ammonium Cation Detergents to Denature Proteins, and Kits for Making Them | AGILENT TECHNOLOGIES, INC. (US) | 2021-12-02 | — | — | US | claimed |
| WO-2026099181-A1 | DEVICE CAPABLE OF STAIN-FREE DEBONDING ON DEMAND | TESA SE (DE) | 2026-05-15 | — | — | WO | disclosed |
| US-11858961-B2 | Solutions of quaternary and tertiary ammonium cation detergents to denature proteins, and kits for making them | AGILENT TECHNOLOGIES, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| CN-115448976-A | Use of quaternary ammonium cation and tertiary ammonium cation detergents in protein denaturation | 安捷伦科技有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-109714963-B | Use of quaternary ammonium cation and tertiary ammonium cation detergents in protein denaturation | 安捷伦科技有限公司 | 2022-08-09 | — | — | CN | disclosed |
| US-20210371454-A1 | Solutions of Quaternary and Tertiary Ammonium Cation Detergents to Denature Proteins, and Kits for Making Them | AGILENT TECHNOLOGIES, INC. (US) | 2021-12-02 | — | — | US | disclosed |
| US-11111268-B2 | Use of quaternary and tertiary ammonium cations to denature proteins | AGILENT TECHNOLOGIES, INC. (US) | 2021-09-07 | — | — | US | disclosed |
| EP-3500097-A1 | USE OF QUATERNARY AND TERTIARY AMMONIUM CATION DETERGENTS TO DENATURE PROTEINS | Prozyme, Inc. (US) | 2019-06-26 | — | — | EP | disclosed |
| US-20190169230-A1 | Use of Quaternary and Tertiary Ammonium Cations to Denature Proteins | PROZYME, INC. (US) | 2019-06-06 | — | — | US | disclosed |
| CN-109714963-A | Use of quaternary ammonium cation and tertiary ammonium cation detergents in protein denaturation | 普若泽米有限公司 | 2019-05-03 | — | — | CN | disclosed |
| WO-2018035386-A1 | USE OF QUATERNARY AND TERTIARY AMMONIUM CATION DETERGENTS TO DENATURE PROTEINS | PROZYME, INC. (US) | 2018-02-22 | — | — | WO | disclosed |
| CN-103841948-A | Method | PERACHEM LTD | 2014-06-04 | — | — | CN | disclosed |
| EP-2216326-B1 | Biologically acceptable choline compounds and their use as tensides | UNIV REGENSBURG (DE) | 2013-09-25 | — | — | EP | disclosed |
| US-20110192789-A1 | METAL OR METAL OXIDE DEPOSITED FIBROUS MATERIALS | DREXEL UNIVERSITY (US) | 2011-08-11 | — | — | US | disclosed |
| WO-2010120730-A1 | HAZARDOUS SUBSTANCE REMOVING MATERIALS, APPARATUS AND METHODS | GLOBAL PROTECTION USA, INC. (US) | 2010-10-21 | — | — | WO | disclosed |
| EP-2216326-A2 | Biologically acceptable choline compounds and their use as tensides | Universität Regensburg (DE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2004029017-A1 | NOVEL QUATERNARY AMMONIUM COMPOUNDS | COOEE BIOSCIENCES LIMITED (AU) | 2004-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11111268-B2 | Use of quaternary and tertiary ammonium cations to denature proteins | PDIA3, STOM, PDIA6 | RECQL 3194/4885TSHR 2389/4885GLA 372/4885 |
| US-20190169230-A1 | Use of Quaternary and Tertiary Ammonium Cations to Denature Proteins | PDIA3, STOM, PDIA6 | RECQL 3194/4885TSHR 2389/4885GLA 372/4885 |
| US-11858961-B2 | Solutions of quaternary and tertiary ammonium cation detergents to denature proteins, and kits for making them | STOM, PDIA3, PDIA5 | RECQL 2779/4885TSHR 2123/4885GLA 309/4885 |
| US-20210371454-A1 | Solutions of Quaternary and Tertiary Ammonium Cation Detergents to Denature Proteins, and Kits for Making Them | STOM, PDIA3, PDIA5 | RECQL 2779/4885TSHR 2123/4885GLA 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.