Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 10/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22911158 | 0.91 | ENPP2 (0.38) | HTR2BSLC6A7 | |
| SCHEMBL16759823 | 0.88 | PAX8 (0.48) | PAX8ABL1BCRNAMPTGHSR | |
| SCHEMBL22911061 | 0.88 | PAX8 (0.48) | PAX8ABL1BCRNAMPTGHSR | |
| SCHEMBL22911141 | 0.86 | HTR2B (0.40) | GHSRHTR2B | |
| SCHEMBL22910791 | 0.85 | HTR2B (0.39) | GHSRHTR2B | |
| SCHEMBL22910877 | 0.83 | GHSR (0.40) | GHSR | |
| SCHEMBL22911082 | 0.83 | LMNA (0.34) | HSD11B1 | |
| SCHEMBL22911171 | 0.83 | MGLL (0.37) | GHSRHTR2BSLC6A7 | |
| SCHEMBL22910986 | 0.81 | AKR1C3 (0.44) | — | |
| SCHEMBL22910998 | 0.81 | CPS1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210015792-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | HOFFMANN-LA ROCHE INC. (US) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210015792-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | NPY1R, NPY2R, DECR1 | PAX8 3366/4885ABL1 1748/4885BCR 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.