Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912270 | 0.79 | SMN1; SMN2 (0.34) | CSF1RPDE2AMEN1KMT2AMAPK1 | |
| SCHEMBL19805996 | 0.78 | SDHB (0.46) | PDE2APDE3AMEN1KMT2ATP53 | |
| SCHEMBL22912306 | 0.72 | L3MBTL1 (0.35) | NPC1RAB9ACSF1RMEN1KMT2A | |
| SCHEMBL28307450 | 0.69 | SDHB (0.39) | NPC1RAB9APDE2APDE3AMEN1 | |
| SCHEMBL19805988 | 0.66 | SDHB (0.53) | PDE2APDE3AMAPK1HSD17B10TP53 | |
| SCHEMBL22912212 | 0.65 | SDHB (0.46) | PDE2APDE3ATP53MAPT | |
| SCHEMBL22912277 | 0.64 | SDHB (0.48) | PDE2APDE3ATP53MAPT | |
| SCHEMBL20985660 | 0.63 | SDHB (0.63) | — | |
| SCHEMBL29976635 | 0.62 | TP53 (0.37) | PDE2APDE3AMEN1KMT2AMAPK1 | |
| SCHEMBL23747248 | 0.61 | TDP1 (0.58) | KDM4EMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |