Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806009 | 1.00 | L3MBTL1 (0.35) | L3MBTL1GPBAR1ALDH1A1NPC1HTT | |
| SCHEMBL19806002 | 0.73 | SDHB (0.53) | LMNAPTGDR | |
| SCHEMBL22912307 | 0.72 | NPC1 (0.33) | ALDH1A1NPC1HTTRAB9ACSF1R | |
| SCHEMBL22912270 | 0.70 | SMN1; SMN2 (0.34) | SMN1; SMN2CSF1RLMNAMEN1KMT2A | |
| SCHEMBL28306291 | 0.68 | SDHB (0.41) | L3MBTL1ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL29976635 | 0.63 | TP53 (0.37) | L3MBTL1ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL21019858 | 0.62 | KDM4E (0.34) | L3MBTL1ALDH1A1HTTLMNAMEN1 | |
| SCHEMBL22912302 | 0.62 | SDHB (0.54) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL29976590 | 0.60 | SDHB (0.71) | — | |
| SCHEMBL20985740 | 0.60 | SDHB (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |