SCHEMBL22912583

SCHEMBL22912583

COCc1ncc(Cl)cc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 1/20 0.41
PLAU P00749 1/20 0.35
MAPK1 P28482 3/20 0.34
MAPK14 Q16539 2/20 0.34
MAPKAPK5 Q8IW41 2/20 0.34
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
APLNR P35414 2/20 0.32
P2RX3 P56373 1/20 0.32
P2RX2 Q9UBL9 1/20 0.32
NAAA Q02083 1/20 0.32
RXRA P19793 3/20 0.32
GRIN1 Q05586 3/20 0.32
GRIN2B Q13224 3/20 0.32
HTT P42858 1/20 0.32
S1PR4 O95977 1/20 0.32
TRPM5 Q9NZQ8 1/20 0.31
LTA4H P09960 1/20 0.31
KCNH2 Q12809 1/20 0.31
GABRA1 P14867 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22912581 0.81 AGBL2 (0.40) KLKB1MAPK1MAPK14MAPKAPK5NAAA
SCHEMBL22912582 0.81 L3MBTL1 (0.41) PLAUMAPK1TDP1L3MBTL1HTT
SCHEMBL25124308 0.79 LMNA (0.37) MAPK1MAPK14MAPKAPK5TDP1P2RX3
SCHEMBL10272604 0.79 CRHR1 (0.38) MAPK1APLNRP2RX3P2RX2HTT
SCHEMBL9952921 0.79 PLAU (0.36) KLKB1PLAUMAPK1L3MBTL1P2RX3
SCHEMBL31539781 0.78 PLAU (0.38) KLKB1PLAUTDP1L3MBTL1S1PR4
SCHEMBL22048116 0.78 TET2 (0.30) NAAA
SCHEMBL10235257 0.76 S1PR1 (0.32) MAPK1TDP1L3MBTL1P2RX3P2RX2
Hydrochloric Acid SCHEMBL9953137 0.75 S1PR1 (0.31) MAPK1HTTTRPM5LTA4HKCNH2
SCHEMBL25023639 0.75 S1PR1 (0.34) PLAUMAPK1HTTTRPM5LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240229063-A1 TRANSGENIC CORN EVENT ZM_CSM63715 AND METHODS FOR DETECTION AND USES THEREOF MONSANTO TECHNOLOGY LLC (US) 2024-07-11 US disclosed
US-20240025862-A1 SUBSTITUTED N-PHENYLURACILS AND SALTS THEREOF, AND USE THEREOF AS HERBICIDAL ACTIVE SUBSTANCES BAYER AKTIENGESELLSCHAFT (DE) 2024-01-25 US disclosed
WO-2023161172-A1 SUBSTITUTED N-BENZOIC ACID URACILS AND SALTS THEREOF, AND USE THEREOF AS HERBICIDAL ACTIVE SUBSTANCES BAYER AKTIENGESELLSCHAFT (DE) 2023-08-31 WO disclosed
EP-4230621-A1 SUBSTITUTED N-BENZOIC ACID URACILS, THEIR SALTS AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS Bayer AG (DE) 2023-08-23 EP disclosed
EP-4230620-A1 SUBSTITUTED N-AMINO-N-BENZOIC ACID URACILS, THEIR SALTS AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS Bayer Aktiengesellschaft (DE) 2023-08-23 EP disclosed
WO-2021013800-A1 SUBSTITUTED N-PHENYL-N-AMINOUARCILS AND SALTS THEREOF AND USE THEREOF AS HERBICIDAL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 2021-01-28 WO disclosed
WO-2021013799-A1 SUBSTITUTED N-PHENYL URACILS, SALTS THEREOF AND THEIR USE AS HERBICIDAL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 2021-01-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240025862-A1 SUBSTITUTED N-PHENYLURACILS AND SALTS THEREOF, AND USE THEREOF AS HERBICIDAL ACTIVE SUBSTANCES PFAS, DDT, NOTUM KLKB1 4881/4885PLAU 3581/4885MAPK1 2350/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.