Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354003 | 0.78 | SIRT2 (0.51) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL4754296 | 0.77 | SIRT2 (0.61) | ALDH1A1LMNASMN1; SMN2SIRT2POLB | |
| SCHEMBL5355132 | 0.76 | F2RL3 (0.62) | ALDH1A1LMNASMN1; SMN2MAPK1SIRT2 | |
| SCHEMBL5359539 | 0.75 | MAPT (0.58) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL5358132 | 0.74 | DYRK1A (0.47) | PDE5AALDH1A1LMNASMN1; SMN2HIF1A | |
| SCHEMBL5354579 | 0.74 | SIRT2 (0.49) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL7113697 | 0.74 | POLB (0.74) | ALDH1A1LMNASMN1; SMN2MAPK1POLB | |
| SCHEMBL5359254 | 0.73 | HTR6 (0.61) | LMNASMN1; SMN2CYP3A4CYP2D6CA12 | |
| SCHEMBL187837 | 0.73 | PDE5A (1.00) | PDE5AALDH1A1LMNASMN1; SMN2HIF1A | |
| SCHEMBL29352550 | 0.73 | PDE5A (1.00) | PDE5AALDH1A1LMNASMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106233141-A | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell | 罗伯特·I·汉金 | 2016-12-14 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109689649-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2022-07-19 | — | — | CN | disclosed |
| CN-109689664-B | Tricyclic heteroaryl substituted quinoline and azaquinoline compounds as PAR4 inhibitors | 百时美施贵宝公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-109689642-B | Monocyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-106470995-A | Imidazo [1,2-a ] pyridines as soluble guanylate cyclase stimulators for the treatment of cardiovascular diseases | 拜耳医药股份有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-104159899-B | Substituted triazine derivatives and their use as activators of soluble guanylate cyclase | 拜耳知识产权有限责任公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106459047-A | Imidazo [1,2-a ] pyridines as stimulators of soluble guanylate cyclase for the treatment of cardiovascular diseases | 拜耳医药股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106459037-A | Enantiomers of the n-(2-amino-5-fluoro-2-methylpentyl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide, as well as of the di- and trifluoro derivatives for the treatment of cardiovascular diseases | 拜耳医药股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106459090-A | 3-(pyrimidine-2-yl)imidazo[1,2-A]pyridines | 拜耳制药股份公司 | 2017-02-22 | — | — | CN | disclosed |
| US-7989650-B2 | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs | HEMOCORM LIMITED (GB) | 2011-08-02 | — | — | US | disclosed |
| EP-2135605-A2 | Therapeutic delivery of carbon monoxide | Hemocorm Limited (GB) | 2009-12-23 | — | — | EP | disclosed |
| US-7176230-B2 | Synthesis of indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) as anti-platelet agents | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2007-02-13 | — | — | US | disclosed |
| US-20060127501-A1 | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs | HEMOCORM LIMITED (GB) | 2006-06-15 | — | — | US | disclosed |
| US-20060115542-A1 | THERAPEUTIC DELIVERY OF CARBON MONOXIDE | HEMOCORM LIMITED (GB) | 2006-06-01 | — | — | US | disclosed |
| US-20060106041-A1 | Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethy 1-2' -furyl) indazole (YC-1) as anti-platelet agents | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2006-05-18 | — | — | US | disclosed |
| US-7045140-B2 | Therapeutic delivery of carbon monoxide | HEMOCORM LIMITED (GB) | 2006-05-16 | — | — | US | disclosed |
| EP-1399147-A2 | THERAPEUTIC DELIVERY OF CARBON MONOXIDE | Northwick Park Institute For Medical Research (GB) | 2004-03-24 | — | — | EP | disclosed |
| US-20030064114-A1 | Therapeutic delivery of carbon monoxide | HEMOCORM LIMITED (GB) | 2003-04-03 | — | — | US | disclosed |
| WO-2002092075-A2 | THERAPEUTIC DELIVERY OF CARBON MONOXIDE | NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH (GB) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106041-A1 | Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethy 1-2' -furyl) indazole (YC-1) as anti-platelet agents | PFKP, HMOX1, TPH1 | PDE5A 736/4885ALDH1A1 1624/4885LMNA 3752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.