SCHEMBL5359539

SCHEMBL5359539

c1ccc(Cn2cc(-c3ccco3)c3ccccc32)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.58
NPSR1 Q6W5P4 3/20 0.58
KDM4E B2RXH2 2/20 0.58
MEN1 O00255 2/20 0.58
ALDH1A1 P00352 2/20 0.58
KMT2A Q03164 2/20 0.58
GAA P10253 1/20 0.58
ADORA1 P30542 1/20 0.56
SIRT2 Q8IXJ6 1/20 0.53
HTR6 P50406 1/20 0.51
HTT P42858 2/20 0.50
NPY1R P25929 1/20 0.50
NPY2R P49146 1/20 0.50
ENPP2 Q13822 1/20 0.49
HSD17B10 Q99714 1/20 0.49
CHRNB2 P17787 1/20 0.49
CHRNA7 P36544 1/20 0.49
CHRNA4 P43681 1/20 0.49
CYP19A1 P11511 1/20 0.49
TSHR P16473 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4754296 0.78 SIRT2 (0.61) MEN1ALDH1A1KMT2AADORA1SIRT2
SCHEMBL2292350 0.75 PDE5A (0.57) MAPTNPSR1KDM4EMEN1ALDH1A1
SCHEMBL5354003 0.74 SIRT2 (0.51) MAPTNPSR1KDM4EMEN1ALDH1A1
SCHEMBL7441180 0.73 SIRT2 (0.53) MEN1ALDH1A1KMT2ASIRT2HTR6
SCHEMBL5355132 0.72 F2RL3 (0.62) NPSR1MEN1ALDH1A1KMT2AADORA1
SCHEMBL7441184 0.72 F2RL3 (0.55) NPSR1MEN1ALDH1A1KMT2AADORA1
SCHEMBL28742332 0.71 L3MBTL1 (0.68) MAPTNPSR1KDM4EMEN1ALDH1A1
SCHEMBL5622616 0.71 SMN1; SMN2 (0.60) MAPTNPSR1MEN1ALDH1A1KMT2A
SCHEMBL5357541 0.71 SIRT2 (0.53) MEN1ALDH1A1KMT2ASIRT2HTR6
SCHEMBL8166825 0.71 SIRT2 (0.68) SIRT2PDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7176230-B2 Synthesis of indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) as anti-platelet agents INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2007-02-13 US disclosed
US-20060106041-A1 Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethy 1-2' -furyl) indazole (YC-1) as anti-platelet agents INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2006-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060106041-A1 Synthesis of indole analogs of 1-benzyl-3-(5'-hydroxymethy 1-2' -furyl) indazole (YC-1) as anti-platelet agents PFKP, HMOX1, TPH1 MAPT 4311/4885NPSR1 2508/4885KDM4E 962/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.