Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477467 | 0.71 | DRD2 (0.47) | SMN1; SMN2GFER | |
| SCHEMBL25699191 | 0.68 | ALDH1A1 (0.46) | — | |
| SCHEMBL14330930 | 0.65 | ADRA2A (0.41) | — | |
| SCHEMBL14329032 | 0.65 | GABRA1 (0.41) | — | |
| SCHEMBL11686432 | 0.64 | ALDH1A1 (0.46) | — | |
| SCHEMBL20803992 | 0.64 | ASIC3 (0.49) | — | |
| SCHEMBL23329957 | 0.64 | PNMT (0.50) | — | |
| SCHEMBL20883624 | 0.63 | — | — | |
| SCHEMBL18521866 | 0.62 | GFER (0.47) | SMN1; SMN2GFER | |
| SCHEMBL13588584 | 0.62 | GAA (0.52) | GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584748-B2 | Spirocyclic compounds | C4 THERAPEUTICS, INC. (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210032245-A1 | SPIROCYCLIC COMPOUNDS | C4 THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210032245-A1 | SPIROCYCLIC COMPOUNDS | CRBN, RBX1, XIAP | SMN1; SMN2 2170/4885GFER 3137/4885 |
| US-11584748-B2 | Spirocyclic compounds | CRBN, RBX1, XIAP | SMN1; SMN2 2170/4885GFER 3137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.