Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 16/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22959000 | 0.86 | TLR7 (0.39) | TLR7TLR8ALDH1A1 | |
| SCHEMBL22959028 | 0.78 | TLR7 (0.40) | TLR7TLR8 | |
| SCHEMBL22959007 | 0.78 | EIF4A1 (0.37) | TLR7TLR8 | |
| SCHEMBL15502335 | 0.74 | TLR7 (0.60) | TLR7TLR8CYP2C9 | |
| SCHEMBL22958959 | 0.73 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL15723560 | 0.72 | DHFR (0.50) | TLR7TLR8ALDH1A1CYP1A2 | |
| SCHEMBL24384588 | 0.71 | TLR8 (0.65) | TLR7TLR8 | |
| SCHEMBL22826036 | 0.71 | TLR8 (0.65) | TLR7TLR8 | |
| SCHEMBL22958999 | 0.71 | CYP2C9 (0.59) | TLR7TLR8CYP1A2CYP2C9 | |
| SCHEMBL29492937 | 0.71 | TLR8 (0.65) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278964-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF | Janssen Sciences Ireland Unlimited Company (IE) | 2023-09-07 | — | — | US | disclosed |
| US-20210040046-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF | Janssen Sciences Ireland Unlimi (IE) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040046-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF | HRH4, HRH3, HNMT | TLR7 52/4885TLR8 400/4885ALDH1A1 1960/4885 |
| US-20230278964-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF | QDPR, PADI2, PEPD | TLR7 728/4885TLR8 584/4885ALDH1A1 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.