Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29446073 | 1.00 | ADRB2 (0.34) | ADRB2PDE2AAPPCYP1A2KDM1A | |
| SCHEMBL30636536 | 0.81 | KDM1A (0.34) | PDE2ACYP1A2KDM1ACYP2D6CYP2C9 | |
| SCHEMBL20972130 | 0.81 | KDM1A (0.34) | PDE2ACYP1A2KDM1ACYP2D6CYP2C9 | |
| SCHEMBL22021976 | 0.80 | ESR1 (0.38) | PDE2ACYP1A2KDM1ACYP2D6CYP2C9 | |
| SCHEMBL4153765 | 0.78 | ALOX15 (0.46) | PDE2AAPPKDM1ARCOR1KCNH2 | |
| SCHEMBL1104683 | 0.78 | ALDH1A1 (0.41) | CYP1A2KDM1ACYP2C19RCOR1KCNH2 | |
| SCHEMBL16046268 | 0.76 | KDM1A (0.36) | PDE2AAPPKDM1ARCOR1KCNH2 | |
| SCHEMBL31082039 | 0.75 | PDE2A (0.41) | PDE2AAPPKDM1ARCOR1KCNH2 | |
| SCHEMBL25341394 | 0.74 | PDE2A (0.35) | PDE2AAPPKDM1AKCNH2ALOX15 | |
| SCHEMBL27858715 | 0.73 | KDM1A (0.39) | PDE2AKDM1ARCOR1KCNH2KDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4007752-B1 | KIF18A INHIBITORS | AMGEN INC (US) | 2025-09-24 | — | — | EP | disclosed |
| US-20220289724-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2022-09-15 | — | — | US | disclosed |
| EP-4007752-A1 | KIF18A INHIBITORS | Amgen Inc. (US) | 2022-06-08 | — | — | EP | disclosed |
| CN-114302880-A | KIF18A inhibitors | 美国安进公司 | 2022-04-08 | — | — | CN | disclosed |
| WO-2021026098-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2021-02-11 | — | — | WO | disclosed |
| WO-2021026098-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2021-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289724-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | ADRB2 4461/4885PDE2A 3206/4885APP 3256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.