Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 12/20 | 0.64 |
| ▸ | NPC1 | O15118 | 8/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.64 |
| ▸ | TP53 | P04637 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.61 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.61 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.61 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.61 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14654842 | 0.85 | LMNA (0.63) | PKMTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23011784 | 0.84 | PKM (0.68) | PKMTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23011777 | 0.82 | PKM (0.79) | PKMTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7716934 | 0.81 | RAB9A (0.81) | TSHRRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL12838359 | 0.81 | NPC1 (0.70) | TSHRRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL7715871 | 0.81 | NPSR1 (0.73) | PKMTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7717504 | 0.81 | RAB9A (0.58) | PKMRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL23011783 | 0.80 | PKM (0.63) | PKMTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7716927 | 0.80 | PTPN2 (0.75) | PKMRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL23011774 | 0.79 | ALDH1A1 (0.84) | TSHRRAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220280644-A1 | \"TRPswitch\" - A STEP FUNCTION CHEMO-OPTOGENETIC LIGAND | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-09-08 | — | — | US | disclosed |
| EP-4009972-A1 | \"TRPSWITCH\" - A STEP FUNCTION CHEMO-OPTOGENETIC LIGAND | University of Utah Research Foundation (US) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021030165-A1 | \"TRPSWITCH\" − A STEP FUNCTION CHEMO-OPTOGENETIC LIGAND | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021030165-A1 | \"TRPSWITCH\" − A STEP FUNCTION CHEMO-OPTOGENETIC LIGAND | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2021-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220280644-A1 | \"TRPswitch\" - A STEP FUNCTION CHEMO-OPTOGENETIC LIGAND | TRPA1, TRPC3, TRPV1 | PKM 4051/4885TSHR 2264/4885RAB9A 2047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.