Water

Water

SCHEMBL2300544

NC(CC(=O)O)(CC(=O)O)C(N)(CC(=O)O)CC(=O)O.O.O.[NaH]

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 known ✓ P11229 1/20 0.41
ADRA1A known ✓ P35348 1/20 0.41
MEN1 known ✓ O00255 1/20 0.31
THRB known ✓ P10828 1/20 0.31
ALDH1A1 P00352 2/20 0.41
HMGCR P04035 1/20 0.41
TBXA2R P21731 1/20 0.41
KDM4E B2RXH2 1/20 0.40
CYP2C19 P33261 2/20 0.39
HIF1A Q16665 2/20 0.39
TSHR P16473 2/20 0.39
CYP2D6 P10635 1/20 0.39
GLRA1 P23415 1/20 0.37
SLC6A9 P48067 1/20 0.37
OR51E2 Q9H255 1/20 0.37
CPT2 P23786 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
FFAR1 O14842 1/20 0.35
ACLY P53396 3/20 0.33
LDHA P00338 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL4943812 1.00 ALDH1A1 (0.41) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Water SCHEMBL9621712 1.00 ALDH1A1 (0.41) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Water SCHEMBL1273944 1.00 ALDH1A1 (0.41) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Water SCHEMBL4367938 1.00 ALDH1A1 (0.41) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Water SCHEMBL8341016 1.00 ALDH1A1 (0.41) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Water SCHEMBL10640902 1.00 ALDH1A1 (0.41) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Water SCHEMBL7071971 1.00 ALDH1A1 (0.41) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Water SCHEMBL21632412 0.97 ALDH1A1 (0.39) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Water SCHEMBL8395691 0.97 ALDH1A1 (0.39) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Water SCHEMBL8431556 0.97 ALDH1A1 (0.39) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0186436-B1 LIQUID CLEANSING COMPOSITION WARNER-LAMBERT COMPANY (US) 1992-03-18 EP claimed
US-4807649-A WITH METAL SULFATED FATTY ALCOHOL DETERGENT, AMINO CARBOXYLATE OR PHOSPHONATE CHELATING AGENT, AND GELLING AGENT WARNER-LAMBERT COMPANY (US) 1989-02-28 US claimed
US-4701223-A MIXTURE OF DETERGENT AND CHELATE COMPOUNDS WARNER-LAMBERT COMPANY (US) 1987-10-20 US claimed
EP-0186436-A2 Liquid cleansing composition WARNER-LAMBERT COMPANY (US) 1986-07-02 EP claimed
JP-60161919-A None JP disclosed
US-12091540-B2 Grafted polymer bearing pendent cyclic carbonate functional groups COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2024-09-17 US disclosed
WO-2023099638-A1 OPHTHALMIC PHARMACEUTICAL COMPOSITIONS CONTAINING A NITRIC OXIDE-RELEASING PHOSPHODIESTERASE 5 INHIBITOR AND METHOD FOR THE PREPARATION THEREOF NICOX SA (FR) 2023-06-08 WO disclosed
EP-3902791-B1 NOVEL NITROGENOUS DIPOLE COMPOUNDS COMPRISING CYCLIC CARBONATE FUNCTIONS MICHELIN & CIE (FR) 2023-02-08 EP disclosed
CN-114716277-A Water and fertilizer integrated nutrient solution for grapes and fertilizing method thereof 上海交通大学 2022-07-08 CN disclosed
US-20220098400-A1 GRAFTED POLYMER BEARING PENDENT CYCLIC CARBONATE FUNCTIONAL GROUPS COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2022-03-31 US disclosed
CN-113227155-A Rubber composition based on at least one compound bearing cyclic carbonate functions 米其林集团总公司 2021-08-06 CN disclosed
CN-108342351-B Castor protoplast preparation and transformation method 广东海洋大学 2020-11-13 CN disclosed
EP-0294785-B1 MAGENTA DYE-FORMING COUPLER FUJI PHOTO FILM CO., LTD. (JP) 1992-11-25 EP disclosed
EP-0505153-A1 Rubber-reinforced styrene resin composition and process for producing the same JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1992-09-23 EP disclosed
EP-0283938-B1 SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL Fuji Photo Film Co., Ltd. (JP) 1992-08-26 EP disclosed
EP-0484909-A1 Method of forming cyan image with cyan dye forming coupler, and silver halide color photographic material containing the cyan dye forming coupler FUJI PHOTO FILM CO., LTD. (JP) 1992-05-13 EP disclosed
EP-0386931-A1 A novel cyan coupler KONICA CORPORATION (JP) 1990-09-12 EP disclosed
EP-0294785-A2 Magenta dye-forming coupler FUJI PHOTO FILM CO., LTD. (JP) 1988-12-14 EP disclosed
EP-0283938-A1 Silver halide color photographic material Fuji Photo Film Co., Ltd. (JP) 1988-09-28 EP disclosed
JP-S60161919-A AGENT FOR DECOMPOSING LIPID PEROXIDE SANKYO CO LTD 1985-08-23 JP disclosed