Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23009971 | 0.85 | MEN1 (0.39) | MEN1KMT2AHPGDGPR119ALDH1A1 | |
| SCHEMBL23009907 | 0.85 | MEN1 (0.42) | MEN1KMT2AHPGDGPR119ALDH1A1 | |
| SCHEMBL29192762 | 0.80 | KMT2A (0.36) | MEN1KMT2AHPGDGPR119ALDH1A1 | |
| SCHEMBL20029632 | 0.80 | MEN1 (0.35) | MEN1KMT2AHPGDGPR119ALDH1A1 | |
| SCHEMBL4849339 | 0.77 | CRHBP (0.38) | MEN1KMT2AHPGDGPR119ALDH1A1 | |
| SCHEMBL16635020 | 0.76 | ALDH1A1 (0.41) | MEN1KMT2AHPGDGPR119ALDH1A1 | |
| SCHEMBL23009979 | 0.75 | OPRK1 (0.33) | MEN1KMT2AALDH1A1NPSR1LMNA | |
| SCHEMBL23007070 | 0.75 | GPR119 (0.41) | GPR119 | |
| SCHEMBL23009920 | 0.74 | TSHR (0.38) | MEN1KMT2AALDH1A1NPSR1LMNA | |
| SCHEMBL20239906 | 0.74 | CRHBP (0.38) | MEN1KMT2AHPGDGPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584761-B2 | Process of making CFTR modulators | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-02-21 | — | — | US | disclosed |
| WO-2021030554-A1 | PROCESS OF MAKING CFTR MODULATORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584761-B2 | Process of making CFTR modulators | CFTR, SLC26A4, TMEM109 | MEN1 2440/4885KMT2A 4522/4885HPGD 2333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.