Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301215 | 0.87 | CA2 (0.37) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL2299883 | 0.87 | EIF2AK2 (0.41) | PTGS2CA1CA2CA9EIF2AK2 | |
| SCHEMBL2303487 | 0.86 | PTGS2 (0.45) | PTGS2PTGS1ALOX5 | |
| SCHEMBL2301613 | 0.84 | TGFBR1 (0.42) | PTGS2CA1CA2CA9MMP2 | |
| SCHEMBL2300248 | 0.84 | NISCH (0.37) | MMP2ALOX5 | |
| SCHEMBL2302364 | 0.83 | USP2 (0.36) | CA1CA2EIF2AK2ALOX5 | |
| SCHEMBL2300517 | 0.81 | PTGS2 (0.41) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL2302290 | 0.81 | ACVR1 (0.39) | PTGS2PTGS1L3MBTL1CA1CA2 | |
| SCHEMBL2303196 | 0.81 | PTGS2 (0.44) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL2302226 | 0.80 | CA1 (0.34) | PTGS2CA1CA2CA9EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536693-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | Université Laval (CA) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011100840-A1 | SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS | UNIVERSITé LAVAL (CA) | 2011-08-25 | — | — | WO | disclosed |