Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282835 | 0.89 | GABRA1 (0.58) | GABRA1GABRB1HSP90AA1HSP90AB1KMT2A | |
| SCHEMBL31182212 | 0.89 | GABRA1 (0.58) | GABRA1GABRB1HSP90AA1HSP90AB1KMT2A | |
| Formaldehyde SCHEMBL27866505 | 0.83 | GABRA1 (0.52) | GABRA1GABRB1HSP90AA1HSP90AB1KMT2A | |
| SCHEMBL6529715 | 0.76 | GABRA1 (0.44) | GABRA1GABRB1HSP90AA1HSP90AB1KMT2A | |
| SCHEMBL2984801 | 0.75 | ALOX15 (0.48) | GABRA1GABRB1KMT2AALOX15HPGD | |
| SCHEMBL6273718 | 0.73 | ALOX15 (0.46) | GABRA1GABRB1KMT2AALOX15HPGD | |
| SCHEMBL20855723 | 0.73 | ALOX15 (0.46) | GABRA1GABRB1KMT2AALOX15HPGD | |
| SCHEMBL20855720 | 0.73 | ALOX15 (0.46) | GABRA1GABRB1KMT2AALOX15HPGD | |
| SCHEMBL4912678 | 0.72 | LMNA (0.59) | GABRA1GABRB1KMT2AALOX15HPGD | |
| SCHEMBL23037559 | 0.72 | GABRA1 (0.60) | GABRA1GABRB1HSP90AA1HSP90AB1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584724-B2 | Process for synthesis of a phenoxy diaminopyrimidine compound | MERCK SHARP & DOHME LLC (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210122717-A1 | NOVEL PROCESS FOR SYNTHESIS OF A PHENOXY DIAMINOPYRIMIDINE COMPOUND | MERCK SHARP & DOHME CORP. (US) | 2021-04-29 | — | — | US | disclosed |
| EP-3784242-A1 | NOVEL PROCESS FOR SYNTHESIS OF A PHENOXY DIAMINOPYRIMIDINE COMPOUND | Merck Sharp&Dohme Corp. (US) | 2021-03-03 | — | — | EP | disclosed |
| CN-112423756-A | Novel process for the synthesis of phenoxydiaminopyrimidine compounds | 默沙东公司 | 2021-02-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584724-B2 | Process for synthesis of a phenoxy diaminopyrimidine compound | DPYD, DCTPP1, CTDSP1 | GABRA1 3237/4885GABRB1 3348/4885HSP90AA1 3461/4885 |
| US-20210122717-A1 | NOVEL PROCESS FOR SYNTHESIS OF A PHENOXY DIAMINOPYRIMIDINE COMPOUND | DCTPP1, DPYD, CTDSP1 | GABRA1 3146/4885GABRB1 3147/4885HSP90AA1 3603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.