Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 5/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23051565 | 0.89 | SCD5 (0.40) | SCD5CYP11B2ACACBGPR183USP30 | |
| SCHEMBL23051642 | 0.86 | SCD5 (0.47) | SCD5CYP11B2ACACBHDAC2GPR183 | |
| SCHEMBL23051643 | 0.82 | GPR119 (0.46) | SCD5CYP11B2ACACBHDAC2GPR183 | |
| SCHEMBL23887653 | 0.81 | NR1H2 (0.58) | SCD5CYP11B2ACACBHDAC2GPR183 | |
| SCHEMBL25343153 | 0.81 | GPR183 (0.41) | SCD5ACACBHDAC2GPR183HDAC1 | |
| SCHEMBL6114652 | 0.79 | CYP11B2 (0.49) | SCD5CYP11B2ACACBHDAC2GPR183 | |
| SCHEMBL23565946 | 0.79 | PKM (0.45) | SCD5CYP11B2ACACBHDAC2GPR183 | |
| SCHEMBL21124030 | 0.79 | PKM (0.45) | SCD5CYP11B2ACACBHDAC2GPR183 | |
| SCHEMBL21084116 | 0.79 | PKM (0.45) | SCD5CYP11B2ACACBHDAC2GPR183 | |
| SCHEMBL20234376 | 0.78 | CYP11B2 (0.48) | SCD5CYP11B2ACACBHDAC2GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220388978-A1 | CEREBLON E3 LIGASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-12-08 | — | — | US | disclosed |
| WO-2021041664-A1 | CEREBLON E3 LIGASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220388978-A1 | CEREBLON E3 LIGASE INHIBITORS | CRBN, CUL3, UBE3A | SCD5 4877/4885CYP11B2 3804/4885ACACB 3554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.