Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.38 |
| ▸ | CTSS | P25774 | 5/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30030351 | 0.87 | CTSS (0.37) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL30064538 | 0.84 | CTSK (0.44) | CTSKCTSSCTSLCTSBCA1 | |
| SCHEMBL23051973 | 0.83 | GRN (0.39) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL29750396 | 0.81 | CAD (0.39) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL23051981 | 0.80 | GRN (0.40) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL25453637 | 0.79 | MAPK1 (0.41) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL20571233 | 0.79 | GRN (0.40) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL20571234 | 0.79 | GRN (0.40) | CTSKCTSSCTSLCTSBMAPK1 | |
| SCHEMBL22262968 | 0.77 | MAPK1 (0.38) | CTSKCTSSMAPK1GRNSORT1 | |
| SCHEMBL13993198 | 0.77 | GRN (0.43) | CTSKMAPK1GRNSORT1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021038426-A1 | SUBSTITUTED 1,3-PHENYL HETEROARYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-03-04 | — | — | WO | disclosed |