SCHEMBL230618

SCHEMBL230618

NC(=S)Nc1cccc(C(F)(F)F)c1

nearest known ligand 0.71

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.71
ALDH1A1 P00352 7/20 0.70
MAPT P10636 7/20 0.70
NPSR1 Q6W5P4 5/20 0.70
GAA P10253 4/20 0.70
TDP1 Q9NUW8 2/20 0.70
L3MBTL1 Q9Y468 4/20 0.66
KMT2A Q03164 5/20 0.64
MEN1 O00255 4/20 0.64
SMN1; SMN2 Q16637 2/20 0.62
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2D6 P10635 1/20 0.62
CYP2C19 P33261 1/20 0.62
KDM4E B2RXH2 2/20 0.60
HTT P42858 2/20 0.59
LMNA P02545 1/20 0.59
PKM P14618 1/20 0.59
RAB9A P51151 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6985227 0.98 IDO1 (0.69) IDO1ALDH1A1MAPTNPSR1GAA
SCHEMBL9724981 0.88 IDO1 (0.69) IDO1ALDH1A1MAPTNPSR1GAA
SCHEMBL10340526 0.86 L3MBTL1 (0.71) IDO1ALDH1A1MAPTNPSR1GAA
SCHEMBL7175227 0.85 MAPT (0.86) IDO1ALDH1A1MAPTNPSR1GAA
SCHEMBL2467470 0.83 IDO1 (1.00) IDO1ALDH1A1MAPTNPSR1GAA
SCHEMBL27903789 0.83 MAPT (0.61) IDO1ALDH1A1MAPTNPSR1GAA
SCHEMBL1883169 0.82 CYP1A2 (0.61) IDO1ALDH1A1MAPTNPSR1GAA
SCHEMBL11593120 0.82 MAPT (0.70) IDO1ALDH1A1MAPTNPSR1GAA
SCHEMBL20560252 0.82 MAPT (0.70) IDO1ALDH1A1MAPTNPSR1GAA
SCHEMBL1999954 0.82 ALDH1A1 (0.61) IDO1ALDH1A1MAPTNPSR1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210283023-A1 Dual-Curing Dental Compositions with High Stability JAMES R. GLIDEWELL DENTAL CERAMICS, INC. 2021-09-16 US claimed
US-20200268615-A1 Dual-Curing Dental Compositions with High Stability JAMES R. GLIDEWELL DENTAL CERAMICS, INC. 2020-08-27 US claimed
CN-111410283-A Agent for removing chloride ions in strongly acidic copper-containing wastewater and method for removing chloride by using same 中国科学院生态环境研究中心 2020-07-14 CN claimed
CN-102276548-A Method for synthesizing 2-iminothiazolidine-4-one and derivatives thereof 2011-12-14 CN claimed
EP-1751136-A2 NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER AMGEN INC. (US) 2007-02-14 EP claimed
WO-2005113494-A2 NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER AMGEN INC. (US) 2005-12-01 WO claimed
EP-1005459-A1 SUBSTITUTED ISOQUINOLINES AS ANTICONVULSIVANTS SMITHKLINE BEECHAM PLC (GB) 2000-06-07 EP claimed
WO-1999014197-A1 SUBSTITUTED ISOQUINOLINES AS ANTICONVULSIVANTS SMITHKLINE BEECHAM PLC (GB) 1999-03-25 WO claimed
CN-120413795-A Application of trifluoromethyl phenylthiourea in lithium-sulfur battery electrolyte, application of lithium-sulfur battery electrolyte and lithium-sulfur battery 内蒙古民族大学 2025-08-01 CN disclosed
US-20250051314-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING PARIS SCIENCES ET LETTRES (FR) 2025-02-13 US disclosed
US-20250011315-A1 ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF PRISM MEDICINES, INC. 2025-01-09 US disclosed
US-20240390333-A1 NEUROPROTECTIVE COMPOSITIONS AND METHODS OF USING THE SAME THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2024-11-28 US disclosed
CN-107629022-B Antibacterial synergist and preparation method and application thereof 上海医药工业研究院 2024-11-12 CN disclosed
EP-4444308-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING Institut Curie (FR) 2024-10-16 EP disclosed
EP-0446802-B1 Iminothiazolines, their production and use as herbicides, and intermediates for their production SUMITOMO CHEMICAL CO (JP) 1995-06-07 EP disclosed
US-5244863-A Iminothiazolines, their production and use as herbicides, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-09-14 US disclosed
EP-0446802-A1 Iminothiazolines, their production and use as herbicides, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-09-18 EP disclosed
US-5000775-A 2-amino-4,5-disubstituted-oxazole/thiazole compounds as herbicide antidotes MONSANTO COMPANY (US) 1991-03-19 US disclosed
US-4933355-A ALDOSE REDUCTASE INHIBITORS SANKYO COMPANY LIMITED (JP) 1990-06-12 US disclosed
US-4626537-A Guanidines, pharmaceutical compositions and use CIBA-GEIGY CORPORATION (US) 1986-12-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250011315-A1 ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF AHR, ARNT, HCAR1 IDO1 244/4885ALDH1A1 289/4885MAPT 4673/4885
US-20250051314-A1 SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING STAT1, IFNG, IRF2BP2 IDO1 1124/4885ALDH1A1 4394/4885MAPT 4087/4885
US-20240390333-A1 NEUROPROTECTIVE COMPOSITIONS AND METHODS OF USING THE SAME GAP43, NLN, SMN1; SMN2 IDO1 3482/4885ALDH1A1 1731/4885MAPT 24/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.