SCHEMBL23069401

SCHEMBL23069401

COc1ccc(C(OC[C@@](CO)(CO[Si](C(C)C)(C(C)C)C(C)C)OC(CO)n2cnc3c(=O)[nH]c(NC(=O)C(C)C)nc32)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TYMP P19971 1/20 0.36
▸ CDK5 Q00535 3/20 0.35
▸ CDK5R1 Q15078 3/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ PDE9A O76083 8/20 0.33
▸ NPC1 O15118 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ CCNE2 O96020 1/20 0.31
▸ CCNE1 P24864 1/20 0.31
▸ CDK2 P24941 1/20 0.31
▸ PDE5A O76074 2/20 0.30
▸ PDE1B Q01064 2/20 0.30
▸ PDE4D Q08499 2/20 0.30
▸ PDE4A P27815 1/20 0.30
▸ PDE4B Q07343 1/20 0.30
▸ PDE4C Q08493 1/20 0.30
▸ PDE7A Q13946 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23069400 1.00 TYMP (0.36) TYMPCDK5CDK5R1KDM4EPDE9A
SCHEMBL23243935 0.89 KDM4E (0.33) TYMPCDK5CDK5R1KDM4EPDE9A
SCHEMBL23243936 0.89 KDM4E (0.33) TYMPCDK5CDK5R1KDM4EPDE9A
SCHEMBL29770528 0.82 CDK5 (0.37) TYMPCDK5CDK5R1CCNE2CCNE1
SCHEMBL23243951 0.82 CDK5 (0.37) TYMPCDK5CDK5R1CCNE2CCNE1
SCHEMBL23243953 0.82 CDK5 (0.37) TYMPCDK5CDK5R1CCNE2CCNE1
SCHEMBL18065046 0.80 CDK5 (0.39) TYMPCDK5CDK5R1KDM4EPDE9A
SCHEMBL20360605 0.77 CDK5 (0.40) CDK5CDK5R1KDM4EPDE9ANPC1
SCHEMBL31273672 0.76 KDM4E (0.39) TYMPKDM4EPDE9ANPC1LMNA
SCHEMBL23069377 0.75 TYMP (0.44) TYMPKDM4EPDE9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260103480-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME SANOFI SA (FR) 2026-04-16 — — US disclosed
US-20240376137-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME SANOFI SA (FR) 2024-11-14 — — US disclosed
US-11897911-B2 Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same SANOFI (FR) 2024-02-13 — — US disclosed
US-20220372063-A1 OLIGONUCLEOTIDES CONTAINING NUCLEOTIDE ANALOGS SANOFI (FR) 2022-11-24 — — US disclosed
EP-4025582-A1 OLIGONUCLEOTIDES CONTAINING NUCLEOTIDE ANALOGS SANOFI (FR) 2022-07-13 — — EP disclosed
US-20210115075-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME SANOFI (FR) 2021-04-22 — — US disclosed
WO-2021044004-A1 OLIGONUCLEOTIDES CONTAINING NUCLEOTIDE ANALOGS SANOFI (FR) 2021-03-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11897911-B2 Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same RNMT, RRM2B, RRM2 TYMP 138/4885CDK5 1156/4885CDK5R1 613/4885
US-20210115075-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME RNMT, RRM2B, RRM2 TYMP 138/4885CDK5 1156/4885CDK5R1 613/4885
US-20260103480-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME NSUN2, NSUN3, SNRPA TYMP 511/4885CDK5 1279/4885CDK5R1 455/4885
US-20240376137-A1 NUCLEOTIDE PRECURSORS, NUCLEOTIDE ANALOGS AND OLIGOMERIC COMPOUNDS CONTAINING THE SAME RNMT, NSUN2, ADAR TYMP 123/4885CDK5 1370/4885CDK5R1 998/4885
US-20220372063-A1 OLIGONUCLEOTIDES CONTAINING NUCLEOTIDE ANALOGS DCLRE1B, UPF1, IGF2BP1 TYMP 40/4885CDK5 2978/4885CDK5R1 2176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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