Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.58 |
| ▸ | SHBG | P04278 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993010 | 0.85 | MAPT (0.66) | MAPTLMNASERPINA6ALDH1A1SLC22A1 | |
| SCHEMBL604997 | 0.85 | MAPT (0.65) | MAPTLMNASERPINA6ALDH1A1SLC22A1 | |
| SCHEMBL11595349 | 0.85 | MAPT (0.65) | MAPTLMNASERPINA6ALDH1A1SLC22A1 | |
| SCHEMBL24103254 | 0.84 | MAPT (0.69) | MAPTLMNASERPINA6ALDH1A1SLC22A1 | |
| SCHEMBL6445859 | 0.84 | MAPT (0.69) | MAPTLMNASERPINA6ALDH1A1SLC22A1 | |
| SCHEMBL13804528 | 0.83 | MAPT (0.71) | MAPTLMNASERPINA6ALDH1A1SLC22A1 | |
| SCHEMBL13177160 | 0.83 | MAPT (0.71) | MAPTLMNASERPINA6ALDH1A1SLC22A1 | |
| SCHEMBL17302789 | 0.83 | MAPT (0.71) | MAPTLMNASERPINA6ALDH1A1SLC22A1 | |
| SCHEMBL2930366 | 0.83 | MAPT (0.71) | MAPTLMNASERPINA6ALDH1A1SLC22A1 | |
| SCHEMBL3458086 | 0.83 | MAPT (0.71) | MAPTLMNASERPINA6ALDH1A1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250281509-A1 | SEQUENTIAL HORMONE THERAPY TO IMPROVE SURVIVAL AND ENHANCE RESPONSE TO IMMUNE THERAPY IN MEN WITH PROSTATE CANCER | THE JOHNS HOPKINS UNIVERSTY | 2025-09-11 | — | — | US | disclosed |
| US-20240317751-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2024-09-26 | — | — | US | disclosed |
| US-11897885-B2 | Purinone derivative hydrochloride | ONO PHARMACEUTICAL CO., LTD. (JP) | 2024-02-13 | — | — | US | disclosed |
| US-20220177474-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-06-09 | — | — | US | disclosed |
| US-11292795-B2 | Purinone derivative hydrochloride | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-04-05 | — | — | US | disclosed |
| US-20210009593-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-01-14 | — | — | US | disclosed |
| US-10807981-B2 | Purinone derivative hydrochloride | ONO PHARMACEUTICAL CO., LTD. (JP) | 2020-10-20 | — | — | US | disclosed |
| US-20190315748-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-10-17 | — | — | US | disclosed |
| US-10370377-B2 | Purinone derivative hydrochloride | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-08-06 | — | — | US | disclosed |
| US-20180244675-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2018-08-30 | — | — | US | disclosed |
| US-7632813-B2 | Bone densifying agent characterized by use of cathepsin K inhibitor with PTH | ONO PHARMACEUTICAL CO., LTD. (JP) | 2009-12-15 | — | — | US | disclosed |
| EP-2085088-A1 | ADHESIVE PREPARATION | ONO Pharmaceutical Co., Ltd. (JP) | 2009-08-05 | — | — | EP | disclosed |
| US-20090074844-A1 | TRENADERMAL ABSORPTION PREPARATION | ONO PHARMACEUTICAL CO., LTD. (JP) | 2009-03-19 | — | — | US | disclosed |
| EP-1878429-A1 | TRENADERMAL ABSORPTION PREPARATION | Ono Pharmaceutical Co., Ltd. (JP) | 2008-01-16 | — | — | EP | disclosed |
| US-20070238769-A1 | Bone Densifying Agent Characterized By Use Of Cathepsin K Inhibitor With Pth | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-10-11 | — | — | US | disclosed |
| US-20070232586-A1 | Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof | OHMOTO KAZUYUKI | 2007-10-04 | — | — | US | disclosed |
| US-20070197510-A1 | Nitriles and medicinal compositions containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-08-23 | — | — | US | disclosed |
| EP-1741441-A1 | BONE DENSIFYING AGENT CHARACTERIZED BY USE OF CATHEPSIN K INHIBITOR WITH PTH | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-10 | — | — | EP | disclosed |
| EP-1739081-A1 | HYDRAZINO-SUBSTITUTED HETEROCYCLIC NITRILE COMPOUNDS AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-03 | — | — | EP | disclosed |
| EP-1724264-A1 | NITRILES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238769-A1 | Bone Densifying Agent Characterized By Use Of Cathepsin K Inhibitor With Pth | CTSK, CTSZ, PTH1R | MAPT 1640/4885LMNA 3735/4885SERPINA6 1661/4885 |
| US-11292795-B2 | Purinone derivative hydrochloride | BTK, P2RY1, P2RY13 | MAPT 4272/4885LMNA 1857/4885SERPINA6 4065/4885 |
| US-20220177474-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | BTK, P2RY1, P2RY13 | MAPT 4272/4885LMNA 1857/4885SERPINA6 4065/4885 |
| US-20240317751-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | BTK, P2RY1, P2RY13 | MAPT 4272/4885LMNA 1857/4885SERPINA6 4065/4885 |
| US-20070197510-A1 | Nitriles and medicinal compositions containing the same as the active ingredient | CTRL, NOS1, CPN1 | MAPT 3433/4885LMNA 1613/4885SERPINA6 913/4885 |
| US-11897885-B2 | Purinone derivative hydrochloride | BTK, P2RY1, P2RY13 | MAPT 4272/4885LMNA 1857/4885SERPINA6 4065/4885 |
| US-20070232586-A1 | Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof | CTRL, PRSS1, CTSZ | MAPT 3947/4885LMNA 3705/4885SERPINA6 1125/4885 |
| US-10807981-B2 | Purinone derivative hydrochloride | BTK, P2RY1, P2RY13 | MAPT 4272/4885LMNA 1857/4885SERPINA6 4065/4885 |
| US-20210009593-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | BTK, P2RY1, P2RY13 | MAPT 4272/4885LMNA 1857/4885SERPINA6 4065/4885 |
| US-20090074844-A1 | TRENADERMAL ABSORPTION PREPARATION | SLC10A2, SLC10A1, TREH | MAPT 4469/4885LMNA 697/4885SERPINA6 2847/4885 |
| US-20190315748-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | BTK, P2RY1, P2RY13 | MAPT 4272/4885LMNA 1857/4885SERPINA6 4065/4885 |
| US-20180244675-A1 | PURINONE DERIVATIVE HYDROCHLORIDE | BTK, P2RY1, P2RY13 | MAPT 4272/4885LMNA 1857/4885SERPINA6 4065/4885 |
| US-10370377-B2 | Purinone derivative hydrochloride | BTK, P2RY1, P2RY13 | MAPT 4272/4885LMNA 1857/4885SERPINA6 4065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.