Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23094282 | 0.82 | TDP1 (0.67) | TDP1L3MBTL1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL23094226 | 0.80 | TDP1 (0.60) | TDP1L3MBTL1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL23094156 | 0.79 | TDP1 (1.00) | TDP1L3MBTL1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL21467764 | 0.77 | TDP1 (1.00) | TDP1L3MBTL1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL23094207 | 0.74 | TDP1 (0.78) | TDP1L3MBTL1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL23094200 | 0.74 | LMNA (0.74) | TDP1L3MBTL1MAPTSMN1; SMN2POLB | |
| SCHEMBL23094203 | 0.73 | L3MBTL1 (1.00) | TDP1L3MBTL1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL23094195 | 0.73 | TDP1 (0.72) | TDP1L3MBTL1MAPK1MAPTRAB9A | |
| SCHEMBL23094273 | 0.71 | TDP1 (0.69) | TDP1L3MBTL1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL4302442 | 0.71 | MAPT (0.61) | TDP1L3MBTL1MAPK1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | GPX4, AIFM2, GPX1 | TDP1 4664/4885L3MBTL1 2077/4885MAPK1 3035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.