Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23089155 | 0.78 | KMT2A (0.34) | KMT2AJMJD6KEAP1CYP19A1 | |
| SCHEMBL23109055 | 0.77 | USP1 (0.34) | KMT2AJMJD6KEAP1 | |
| SCHEMBL23114612 | 0.76 | JMJD6 (0.35) | KMT2AJMJD6NPC1RAB9AKEAP1 | |
| SCHEMBL31512002 | 0.69 | NOS3 (0.46) | KMT2AJMJD6KEAP1MAPK10 | |
| SCHEMBL29153859 | 0.64 | KMT2A (0.44) | KMT2AJMJD6KEAP1MKNK1MKNK2 | |
| SCHEMBL23107329 | 0.64 | MAOA (0.43) | TGFBR1 | |
| SCHEMBL75314 | 0.63 | — | — | |
| SCHEMBL30633585 | 0.62 | CRHR1 (0.36) | KMT2A | |
| SCHEMBL23761304 | 0.62 | MAPK14 (0.40) | — | |
| SCHEMBL18157906 | 0.62 | KMT2A (0.64) | KMT2AJMJD6KEAP1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |
| WO-2021050964-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2021-03-18 | — | — | WO | disclosed |