SCHEMBL2311024

SCHEMBL2311024

O=C1c2ccccc2N=CC2CC=CN12

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ GABRP O00591 1/20 0.34
▸ GABRD O14764 1/20 0.34
▸ GABRA1 P14867 1/20 0.34
▸ GABRB1 P18505 1/20 0.34
▸ GABRG2 P18507 1/20 0.34
▸ GABRB3 P28472 1/20 0.34
▸ GABRA5 P31644 1/20 0.34
▸ GABRA3 P34903 1/20 0.34
▸ GABRA2 P47869 1/20 0.34
▸ GABRB2 P47870 1/20 0.34
▸ GABRA4 P48169 1/20 0.34
▸ GABRE P78334 1/20 0.34
▸ GABRA6 Q16445 1/20 0.34
▸ GABRG1 Q8N1C3 1/20 0.34
▸ GABRG3 Q99928 1/20 0.34
▸ GABRQ Q9UN88 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14071779 1.00 GABRP (0.34) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL29546852 0.74 GABRP (0.33) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL3266517 0.70 ALDH1A1 (0.41) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL3269541 0.70 ALDH1A1 (0.41) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL16069934 0.69 GABRP (0.33) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL16069932 0.68 NOTUM (0.40) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL29482079 0.68 HTR2C (0.33) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL17915849 0.68 PARP1 (0.42) —
SCHEMBL13247401 0.68 NOTUM (0.40) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL31314727 0.67 GABRP (0.32) GABRPGABRDGABRA1GABRB1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624118-B2 Trispecific binding molecules against BCMA and uses thereof NOVARTIS AG (CH) 2026-05-12 — — US disclosed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 — — US disclosed
US-20260056209-A1 ANTI-CCR8 ANTIBODIES AND USES THEREOF GILEAD SCIENCES INC (US) 2026-02-26 — — US disclosed
US-20260035473-A1 BINDING MOLECULES AGAINST BCMA AND USES THEREOFPrivate view NOVARTIS AG (CH) 2026-02-05 — — US disclosed
US-20250361320-A1 ANTI-CEACAM5 ANTIBODIES AND USES THEREOF BRISTOL MYERS SQUIBB CO (US) 2025-11-27 — — US disclosed
US-20250326855-A1 ANTI-GLYCO-CD44 ANTIBODIES AND THEIR USES GO THERAPEUTICS, INC. (US) 2025-10-23 — — US disclosed
US-20250304716-A1 ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES GO THERAPEUTICS, INC. (US) 2025-10-02 — — US disclosed
US-20250223359-A1 CD19 BINDING MOLECULES AND USES THEREOF NOVARTIS AG (CH) 2025-07-10 — — US disclosed
US-20250136701-A1 ANTI-GLYCO-CMET ANTIBODIES AND THEIR USES GO THERAPEUTICS, INC. (US) 2025-05-01 — — US disclosed
US-12275795-B2 Binding molecules against BCMA and uses thereof NOVARTIS AG (CH) 2025-04-15 — — US disclosed
EP-3972993-A1 VARIANT CD58 DOMAINS AND USES THEREOF Novartis AG (CH) 2022-03-30 — — EP disclosed
US-20220089772-A1 ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES GO THERAPEUTICS, INC. (US) 2022-03-24 — — US disclosed
CN-114173810-A Trispecific binding molecules directed against BCMA and uses thereof 诺华股份有限公司 2022-03-11 — — CN disclosed
EP-3169368-B1 LINKERS AND THEIR APPLICATION TOWARDS ADC MEDSHINE DISCOVERY INC (CN) 2021-02-17 — — EP disclosed
EP-2755642-A1 PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES Seattle Genetics, Inc. (US) 2014-07-23 — — EP disclosed
WO-2013055990-A1 PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES SEATTLE GENETICS, INC. (US) 2013-04-18 — — WO disclosed
EP-2558127-A1 TARGETED PYRROLOBENZODIAZAPINE CONJUGATES Seattle Genetics, Inc. (US) 2013-02-20 — — EP disclosed
WO-2011130613-A1 TARGETED PYRROLOBENZODIAZAPINE CONJUGATES SEATTLE GENETICS, INC. (US) 2011-10-20 — — WO disclosed
EP-2350080-A1 UNSYMMETRICAL PYRROLOBENZODIAZEPINE-DIMERS FOR TREATMENT OF PROLIFERATIVE DISEASES Spirogen Limited (GB) 2011-08-03 — — EP disclosed
WO-2010043880-A1 UNSYMMETRICAL PYRROLOBENZODIAZEPINE-DIMERS FOR TREATMENT OF PROLIFERATIVE DISEASES SPIROGEN LIMITED (GB) 2010-04-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250136701-A1 ANTI-GLYCO-CMET ANTIBODIES AND THEIR USES CD2BP2, CSGALNACT1, DNTT GABRP 2221/4885GABRD 2952/4885GABRA1 1847/4885
US-20260056209-A1 ANTI-CCR8 ANTIBODIES AND USES THEREOF CCR8, CCR3, CCR1 GABRP 612/4885GABRD 227/4885GABRA1 448/4885
US-20250326855-A1 ANTI-GLYCO-CD44 ANTIBODIES AND THEIR USES CD44, SIGLEC7, SIGLEC9 GABRP 703/4885GABRD 1556/4885GABRA1 1265/4885
US-20260035473-A1 BINDING MOLECULES AGAINST BCMA AND USES THEREOFPrivate view BCL9, BRCA1, VCAM1 GABRP 1376/4885GABRD 1553/4885GABRA1 424/4885
US-12624118-B2 Trispecific binding molecules against BCMA and uses thereof CD2, CD40, CD22 GABRP 306/4885GABRD 651/4885GABRA1 285/4885
US-20220089772-A1 ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES MUC1, SIGLEC7, SIGLEC9 GABRP 1800/4885GABRD 2084/4885GABRA1 2422/4885
US-20250223359-A1 CD19 BINDING MOLECULES AND USES THEREOF CD22, BCL9, CD2 GABRP 1142/4885GABRD 1986/4885GABRA1 874/4885
US-20250361320-A1 ANTI-CEACAM5 ANTIBODIES AND USES THEREOF EPCAM, CD47, CD44 GABRP 858/4885GABRD 2102/4885GABRA1 687/4885
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS DCLRE1A, CCR3, CCR8 GABRP 466/4885GABRD 1244/4885GABRA1 1288/4885
US-12275795-B2 Binding molecules against BCMA and uses thereof EPCAM, CD40, BCR GABRP 443/4885GABRD 1129/4885GABRA1 487/4885
US-20250304716-A1 ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES MUC1, SIGLEC7, SIGLEC9 GABRP 1800/4885GABRD 2084/4885GABRA1 2422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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