Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3266517 | 1.00 | ALDH1A1 (0.41) | ALDH1A1GAAHPGDHSD17B10CDK4 | |
| SCHEMBL5963318 | 0.83 | GABRA1 (0.41) | ALDH1A1GAAHPGDHSD17B10GABRA1 | |
| SCHEMBL5962947 | 0.80 | CRBN (0.36) | ALDH1A1GAAHPGDHSD17B10NOS1 | |
| SCHEMBL11458112 | 0.77 | CDK5 (0.38) | ALDH1A1GAAHPGDHSD17B10CDK4 | |
| SCHEMBL2600442 | 0.77 | KMT2A (0.41) | ALDH1A1HSD17B10GABRA1GABRG2GABRB3 | |
| SCHEMBL5962874 | 0.77 | KMT2A (0.41) | ALDH1A1HSD17B10GABRA1GABRG2GABRB3 | |
| SCHEMBL19339957 | 0.77 | HTR2C (0.40) | ALDH1A1HSD17B10GABRA1GABRG2GABRB3 | |
| SCHEMBL17915861 | 0.76 | ERBB2 (0.36) | HSD17B10GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL16069934 | 0.75 | GABRP (0.33) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL19339958 | 0.74 | MEN1 (0.38) | ALDH1A1HSD17B10GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550275-B1 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE-BENZOTHIAZOLE OR BENZOXAZOLE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2014-03-12 | — | — | EP | claimed |
| US-11912700-B2 | Anti-proliferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines | PHEON THERAPEUTICS LTD (GB) | 2024-02-27 | — | — | US | disclosed |
| US-11912700-B2 | Anti-proliferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines | PHEON THERAPEUTICS LTD (GB) | 2024-02-27 | — | — | US | disclosed |
| US-20230302142-A1 | Cytotoxic Agents | Pheon Therapeutics Ltd. (GB) | 2023-09-28 | — | — | US | disclosed |
| US-11638760-B2 | Pyrrolobenzodiazepine antibody conjugates | MERSANA THERAPEUTICS, INC. (US) | 2023-05-02 | — | — | US | disclosed |
| US-11638760-B2 | Pyrrolobenzodiazepine antibody conjugates | MERSANA THERAPEUTICS, INC. (US) | 2023-05-02 | — | — | US | disclosed |
| US-20210206763-A1 | Anti-Proliferative Agents | PHEON THERAPEUTICS LTD (GB) | 2021-07-08 | — | — | US | disclosed |
| US-20210107923-A1 | CYTOTOXIC AGENTS | PHEON THERAPEUTICS LTD (GB) | 2021-04-15 | — | — | US | disclosed |
| US-10660901-B2 | Pyrrolobenzodiazepines and conjugates thereof | MERSANA THERAPEUTICS, INC. (US) | 2020-05-26 | — | — | US | disclosed |
| US-10399970-B2 | Pyrridinobenzodiazepine and benzopyrridodiazecine compounds | FEMTOGENIX LIMITED (GB) | 2019-09-03 | — | — | US | disclosed |
| US-7429658-B2 | Synthesis of protected pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| US-7429658-B2 | Synthesis of protected pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2008-09-30 | — | — | US | disclosed |
| US-20080214525-A1 | Alkyl 4- [4- (5-Oxo-2,3,5, 11A-Tetrahydo-5H-Pyrrolo [2, 1-C] [1,4] Benzodiazepine-8-Yloxy) -Butyrylamino]-1H-Pyrrole-2-Carboxylate Derivatives and Related Compounds For the Treatment of a Proliferative Disease | SPIROGEN LIMITED (GB) | 2008-09-04 | — | — | US | disclosed |
| US-7407951-B2 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| WO-2008020456-A2 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-02-21 | — | — | WO | disclosed |
| US-20070249591-A1 | Biaryl Amino Acids and Their Use in Dna Binding Oligomers | SPIROGEN LIMITED (GB) | 2007-10-25 | — | — | US | disclosed |
| US-20070191349-A1 | C8, c8' linked 5-oxo-1,2,3,11a-tetrahydro-5h-pyrrolo[2,1-c][1,4] benzodiazepine dimers with 1h-pyrrole-dicarboxylic acid amide linkers and oligomeric analogs therof as well as related compounds for the treatment of proliferative diseases | SPIROGEN LIMITED (GB) | 2007-08-16 | — | — | US | disclosed |
| US-20070173497-A1 | 11-Hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2007-07-26 | — | — | US | disclosed |
| US-6800622-B1 | DNA BINDING, ANTITUMOUR ACTIVITY | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-10-05 | — | — | US | disclosed |
| US-20040192677-A1 | PYRENE-LINKED PYRROLO[2,1--C][1,4]BENZODIAZEPINE HYBRIDS USEFUL AS ANTI-CANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192677-A1 | PYRENE-LINKED PYRROLO[2,1--C][1,4]BENZODIAZEPINE HYBRIDS USEFUL AS ANTI-CANCER AGENTS | TOP2B, TOP1, PBRM1 | ALDH1A1 1156/4885GAA 2928/4885HPGD 2272/4885 |
| US-20070191349-A1 | C8, c8' linked 5-oxo-1,2,3,11a-tetrahydro-5h-pyrrolo[2,1-c][1,4] benzodiazepine dimers with 1h-pyrrole-dicarboxylic acid amide linkers and oligomeric analogs therof as well as related compounds for the treatment of proliferative diseases | TSPO, GABRD, BCOR | ALDH1A1 1722/4885GAA 1738/4885HPGD 115/4885 |
| US-20210206763-A1 | Anti-Proliferative Agents | CCND2, BRD2, DRD2 | ALDH1A1 3187/4885GAA 1401/4885HPGD 691/4885 |
| US-10399970-B2 | Pyrridinobenzodiazepine and benzopyrridodiazecine compounds | DRD1, XDH, DRD2 | ALDH1A1 1156/4885GAA 4352/4885HPGD 169/4885 |
| US-20210107923-A1 | CYTOTOXIC AGENTS | MKI67, TP53, NFATC1 | ALDH1A1 1520/4885GAA 325/4885HPGD 2961/4885 |
| US-20070249591-A1 | Biaryl Amino Acids and Their Use in Dna Binding Oligomers | PCNA, POLL, DNA2 | ALDH1A1 2474/4885GAA 2871/4885HPGD 4013/4885 |
| US-11638760-B2 | Pyrrolobenzodiazepine antibody conjugates | GABRA4, GABRA1, GABRA2 | ALDH1A1 538/4885GAA 1471/4885HPGD 1806/4885 |
| US-20070173497-A1 | 11-Hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines | H1-10, DRD1, SBDS | ALDH1A1 844/4885GAA 3850/4885HPGD 82/4885 |
| US-20080214525-A1 | Alkyl 4- [4- (5-Oxo-2,3,5, 11A-Tetrahydo-5H-Pyrrolo [2, 1-C] [1,4] Benzodiazepine-8-Yloxy) -Butyrylamino]-1H-Pyrrole-2-Carboxylate Derivatives and Related Compounds For the Treatment of a Proliferative Disease | CCNY, NR0B1, CNR1 | ALDH1A1 2826/4885GAA 3705/4885HPGD 2315/4885 |
| US-20230302142-A1 | Cytotoxic Agents | ANXA11, ANXA5, HAX1 | ALDH1A1 3438/4885GAA 3737/4885HPGD 4473/4885 |
| US-10660901-B2 | Pyrrolobenzodiazepines and conjugates thereof | CD79B, CLTB, FCGR3B | ALDH1A1 1486/4885GAA 1088/4885HPGD 2230/4885 |
| US-11912700-B2 | Anti-proliferative agents comprising substituted benzo[e]pyrido[1,2-a][1,4]diazepines | MKI67, CCND2, CCND1 | ALDH1A1 443/4885GAA 1774/4885HPGD 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.