Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL486989 | 0.98 | ALDH1A1 (0.52) | ALDH1A1SRD5A2L3MBTL1ATMTDP1 | |
| Bromide SCHEMBL232722 | 0.89 | HPGD (0.48) | ALDH1A1SRD5A2L3MBTL1RAB9ALMNA | |
| SCHEMBL320253 | 0.87 | HPGD (0.49) | ALDH1A1SRD5A2L3MBTL1RAB9ALMNA | |
| Bromide SCHEMBL232885 | 0.83 | ALDH1A1 (0.47) | ALDH1A1SRD5A2L3MBTL1ATMTDP1 | |
| SCHEMBL326805 | 0.81 | ALDH1A1 (0.48) | ALDH1A1SRD5A2L3MBTL1ATMTDP1 | |
| SCHEMBL7889494 | 0.74 | ALDH1A1 (0.67) | ALDH1A1SRD5A2L3MBTL1ATMTDP1 | |
| SCHEMBL8094666 | 0.74 | ALDH1A1 (0.67) | ALDH1A1SRD5A2L3MBTL1ATMTDP1 | |
| SCHEMBL9066312 | 0.73 | ALDH1A1 (0.93) | ALDH1A1SRD5A2L3MBTL1ATMTDP1 | |
| SCHEMBL314267 | 0.73 | ALDH1A1 (0.93) | ALDH1A1SRD5A2L3MBTL1ATMTDP1 | |
| SCHEMBL4004691 | 0.72 | LMNA (0.67) | ALDH1A1SRD5A2L3MBTL1ATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004339-A1 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SURMODICS, INC. (US) | 2012-01-05 | — | — | US | claimed |
| US-8039524-B2 | Reagent and method for providing coatings on surfaces | SURMODICS, INC. (US) | 2011-10-18 | — | — | US | claimed |
| US-7883749-B2 | placing an object into a container, filling the container with a 1st solution of nonpolymeric grafting initiator, irradiating, removing the solution from the container, filling the container with a 2ns solution of polymerizable monomer or macromer, bubbling gas through the solution, irradiating; curable | SURMODICS, INC. (US) | 2011-02-08 | — | — | US | claimed |
| US-20100240789-A1 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SURMODICS, INC. (US) | 2010-09-23 | — | — | US | claimed |
| US-7736689-B2 | Reagent and method for providing coatings on surfaces | SURMODICS, INC. (US) | 2010-06-15 | — | — | US | claimed |
| US-20090176030-A1 | METHOD FOR COATING AN OBJECT WITH A GRAFT POLYMER LAYER | SURMODICS, INC. | 2009-07-09 | — | — | US | claimed |
| US-7348055-B2 | Reagent and method for providing coatings on surfaces | SURMODICS, INC. (US) | 2008-03-25 | — | — | US | claimed |
| US-20070292596-A1 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SURMODICS, INC. (US) | 2007-12-20 | — | — | US | claimed |
| EP-1594623-B1 | GRAFTING APPARTUS AND METHOD OF USING | SURMODICS INC (US) | 2007-04-11 | — | — | EP | claimed |
| EP-1465740-A4 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SURMODICS INC (US) | 2006-06-07 | — | — | EP | claimed |
| US-7041174-B2 | Grafting apparatus and method of using | SUNMODICS,INC. (US) | 2006-05-09 | — | — | US | claimed |
| JP-2005514192-A | — | — | 2005-05-19 | — | — | JP | claimed |
| EP-1465740-A1 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SurModics, Inc. (US) | 2004-10-13 | — | — | EP | claimed |
| US-20040161547-A1 | Grafting apparatus and method of using | SURMODICS, INC. | 2004-08-19 | — | — | US | claimed |
| US-20030165613-A1 | Reagent and method for providing coatings on surfaces | Surmodics Coatings, LLC | 2003-09-04 | — | — | US | claimed |
| WO-2003055611-A1 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SURMODICS, INC. (US) | 2003-07-10 | — | — | WO | claimed |
| US-8318263-B2 | Method for coating an object with a graft polymer layer | SURMODICS, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120004339-A1 | REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES | SURMODICS, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| US-5714360-A | CROSSLINKING A SURFACE WITH A TARGET MOLECULE; BIOLOGICAL IMMOBILIZATION; MEDICAL EQUIPMENT; SURFACE TREATMENT | BSI CORPORATION (US) | 1998-02-03 | — | — | US | disclosed |
| WO-1997016544-A1 | WATER SOLUBLE CROSS-LINKING AGENTS | BSI CORPORATION (US) | 1997-05-09 | — | — | WO | disclosed |