SCHEMBL486989

SCHEMBL486989

O=C(c1ccccc1)c1ccc(C[N+]2(Cc3ccc(C(=O)c4ccccc4)cc3)CC[N+](Cc3ccc(C(=O)c4ccccc4)cc3)(Cc3ccc(C(=O)c4ccccc4)cc3)CC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.52
SRD5A2 P31213 3/20 0.50
L3MBTL1 Q9Y468 3/20 0.45
ATM Q13315 2/20 0.45
TDP1 Q9NUW8 1/20 0.45
RAB9A P51151 4/20 0.44
LMNA P02545 3/20 0.44
MAPT P10636 3/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
MAPK13 O15264 1/20 0.44
MAPK12 P53778 1/20 0.44
MAPK11 Q15759 1/20 0.44
MAPK14 Q16539 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
HTT P42858 2/20 0.44
HPGD P15428 4/20 0.44
NPC1 O15118 2/20 0.43
TP53 P04637 1/20 0.43
ALOX15 P16050 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL231360 0.98 ALDH1A1 (0.50) ALDH1A1SRD5A2L3MBTL1ATMTDP1
SCHEMBL320253 0.89 HPGD (0.49) ALDH1A1SRD5A2L3MBTL1RAB9ALMNA
Bromide SCHEMBL232722 0.87 HPGD (0.48) ALDH1A1SRD5A2L3MBTL1RAB9ALMNA
SCHEMBL326805 0.82 ALDH1A1 (0.48) ALDH1A1SRD5A2L3MBTL1ATMTDP1
Bromide SCHEMBL232885 0.81 ALDH1A1 (0.47) ALDH1A1SRD5A2L3MBTL1ATMTDP1
SCHEMBL7889494 0.76 ALDH1A1 (0.67) ALDH1A1SRD5A2L3MBTL1ATMTDP1
SCHEMBL8094666 0.76 ALDH1A1 (0.67) ALDH1A1SRD5A2L3MBTL1ATMTDP1
SCHEMBL9066312 0.74 ALDH1A1 (0.93) ALDH1A1SRD5A2L3MBTL1ATMTDP1
SCHEMBL314267 0.74 ALDH1A1 (0.93) ALDH1A1SRD5A2L3MBTL1ATMTDP1
SCHEMBL7898126 0.74 ALDH1A1 (0.64) ALDH1A1SRD5A2L3MBTL1ATMTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1503813-B1 SILANE COATING COMPOSITION SURMODICS INC (US) 2007-05-30 EP claimed
EP-1594623-B1 GRAFTING APPARTUS AND METHOD OF USING SURMODICS INC (US) 2007-04-11 EP claimed
US-6706408-B2 Silane coating composition SURMODICS, INC. 2004-03-16 US claimed
US-20030215649-A1 First coating layer of a silane compound, a hydrolysis reaction product of the silane compound or a polymeric silane compound, or mixture (free of sulfide group), a second layer of a polymer and a photoactivable crosslinker SURMODICS, INC. 2003-11-20 US claimed
WO-2026090506-A1 MEDICAL DEVICE COATINGS AND METHODS SURMODICS, INC. (US) 2026-04-30 WO disclosed
US-20260108663-A1 LOW PARTICULATE LUBRICIOUS COATING WITH VINYL PYRROLIDONE AND ACIDIC POLYMER-CONTAINING LAYERS SURMODICS INC (US) 2026-04-23 US disclosed
US-20260098225-A1 POLYACRYLIC ACID CONTAINING LUBRICIOUS COATINGS FOR MEDICAL DEVICES WITH ENHANCED PROPERTIES SURMODICS INC (US) 2026-04-09 US disclosed
US-12472288-B2 Lubricious coating for medical device SURMODICS, INC. (US) 2025-11-18 US disclosed
EP-4646241-A1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES WITH ENHANCED DURABILITY SurModics, Inc. (US) 2025-11-12 EP disclosed
US-12441951-B2 Polyacrylic acid containing lubricious coatings for medical devices with enhanced properties SURMODICS, INC. (US) 2025-10-14 US disclosed
EP-4615530-A1 POLYACRYLIC ACID CONTAINING LUBRICIOUS COATINGS FOR MEDICAL DEVICES WITH ENHANCED PROPERTIES SurModics, Inc. (US) 2025-09-17 EP disclosed
US-12409253-B2 Low particulate lubricious coating with vinyl pyrrolidone and acidic polymer-containing layers SURMODICS, INC. (US) 2025-09-09 US disclosed
EP-1503813-B1 SILANE COATING COMPOSITION SURMODICS INC (US) 2007-05-30 EP disclosed
US-20070054127-A1 SILANE COATING COMPOSITIONS, COATING SYSTEMS, AND METHODS Surmodics Coatings, LLC 2007-03-08 US disclosed
WO-2007025059-A1 SILANE COATING COMPOSITIONS, COATING SYSTEMS, AND METHODS SURMODICS, INC. (US) 2007-03-01 WO disclosed
US-20060276894-A1 Hydrophilic polymeric coatings for medical articles SURMODICS, INC. 2006-12-07 US disclosed
EP-1503813-A1 SILANE COATING COMPOSITION SurModics, Inc. (US) 2005-02-09 EP disclosed
US-6706408-B2 Silane coating composition SURMODICS, INC. 2004-03-16 US disclosed
WO-2003097117-A1 SILANE COATING COMPOSITION SURMODICS, INC. (US) 2003-11-27 WO disclosed
US-20030215649-A1 First coating layer of a silane compound, a hydrolysis reaction product of the silane compound or a polymeric silane compound, or mixture (free of sulfide group), a second layer of a polymer and a photoactivable crosslinker SURMODICS, INC. 2003-11-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260098225-A1 POLYACRYLIC ACID CONTAINING LUBRICIOUS COATINGS FOR MEDICAL DEVICES WITH ENHANCED PROPERTIES CUTA, EED, SELP ALDH1A1 135/4885SRD5A2 1647/4885L3MBTL1 3337/4885
US-20260108663-A1 LOW PARTICULATE LUBRICIOUS COATING WITH VINYL PYRROLIDONE AND ACIDIC POLYMER-CONTAINING LAYERS VCL, RAD54L, SELP ALDH1A1 751/4885SRD5A2 1863/4885L3MBTL1 2724/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.