Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | BAD | Q92934 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30920 | 0.88 | MAPT (0.56) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL14021104 | 0.83 | RAB9A (0.62) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL28480483 | 0.78 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL427929 | 0.77 | TUBB4A (0.72) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL154083 | 0.74 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AGLO1SMN1; SMN2 | |
| SCHEMBL6319718 | 0.74 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL31405 | 0.74 | HSD17B1 (0.70) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL8405393 | 0.72 | MAOB (0.64) | ALDH1A1MEN1KMT2AKDM4EHTT | |
| SCHEMBL13833752 | 0.72 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL11007700 | 0.72 | KMT2A (0.66) | ALDH1A1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |