Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.55 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23146 | 0.88 | ALDH1A1 (0.53) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL14021104 | 0.83 | RAB9A (0.62) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL29751988 | 0.80 | HSD17B1 (0.48) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL29751975 | 0.79 | HSD17B1 (0.54) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL427929 | 0.77 | TUBB4A (0.72) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL13833772 | 0.77 | HSD17B1 (0.58) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL8405393 | 0.75 | MAOB (0.64) | MEN1KMT2AHTTALDH1A1KDM4E | |
| SCHEMBL6319718 | 0.74 | ALDH1A1 (0.66) | MAPTMEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL31405 | 0.74 | HSD17B1 (0.70) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL28480483 | 0.73 | ALDH1A1 (0.56) | MAPTMEN1KMT2ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |