Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218018 | 0.88 | LMNA (0.40) | ALDH1A1L3MBTL1KMT2ALMNAPOLB | |
| SCHEMBL28038900 | 0.85 | CYP3A4 (0.43) | ALDH1A1L3MBTL1KMT2ATSHRLMNA | |
| SCHEMBL29009658 | 0.84 | L3MBTL1 (0.38) | ALDH1A1L3MBTL1KMT2ATSHRGSTO1 | |
| SCHEMBL26345840 | 0.81 | CTSS (0.44) | ALDH1A1LMNAPOLBCTSSCTSK | |
| SCHEMBL6822857 | 0.81 | RIPK1 (0.39) | ALDH1A1L3MBTL1KMT2ALMNAPOLB | |
| SCHEMBL4832911 | 0.81 | LMNA (0.41) | ALDH1A1L3MBTL1LMNAPOLBCTSS | |
| SCHEMBL28859253 | 0.81 | L3MBTL1 (0.36) | ALDH1A1L3MBTL1KMT2ATSHRPOLB | |
| SCHEMBL26345821 | 0.77 | POLB (0.41) | ALDH1A1L3MBTL1KMT2ALMNAPOLB | |
| SCHEMBL3160825 | 0.77 | TSHR (0.37) | ALDH1A1L3MBTL1KMT2ATSHRLMNA | |
| SCHEMBL6207086 | 0.77 | L3MBTL1 (0.33) | ALDH1A1L3MBTL1KMT2ATSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006340-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2022006340-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |