Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 5/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23259227 | 0.76 | ELANE (0.36) | ELANEMEN1KMT2AATMKDM1A | |
| SCHEMBL23258688 | 0.71 | MAOA (0.35) | ELANEGPR119CNR2ALOX5APFEN1 | |
| SCHEMBL23258832 | 0.70 | PDE4B (0.40) | ELANE | |
| SCHEMBL2761277 | 0.70 | ELANE (0.49) | ELANEMEN1KMT2AATMKDM1A | |
| SCHEMBL23258869 | 0.70 | ELANE (0.42) | ELANEMEN1KMT2AKDM1APDK2 | |
| SCHEMBL17171697 | 0.70 | PTGDR2 (0.40) | ELANEMEN1KMT2AKDM1AGPR119 | |
| SCHEMBL23258472 | 0.69 | HTR2C (0.43) | HTR6HTR2CNOTUMPDK2PDK4 | |
| SCHEMBL1790296 | 0.69 | PTGDR2 (0.52) | ELANEMEN1KMT2AHTR2C | |
| SCHEMBL23258478 | 0.68 | GABRA1 (0.43) | ELANE | |
| SCHEMBL2221010 | 0.67 | ELANE (0.49) | ELANEKMT2AKDM1ADDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021076938-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |