Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 6/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SI | P14410 | 2/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752808 | 0.90 | DGAT1 (0.39) | DGAT1MMP8ALDH1A1POLBTSHR | |
| SCHEMBL556529 | 0.87 | DGAT1 (0.38) | DGAT1MMP8ALDH1A1POLBTSHR | |
| SCHEMBL4791578 | 0.87 | DGAT1 (0.38) | DGAT1MMP8ALDH1A1POLBTSHR | |
| SCHEMBL17617140 | 0.87 | ALDH1A1 (0.36) | DGAT1MMP8ALDH1A1POLBTSHR | |
| SCHEMBL17617189 | 0.87 | ALDH1A1 (0.36) | DGAT1MMP8ALDH1A1POLBTSHR | |
| SCHEMBL3169320 | 0.85 | DGAT1 (0.37) | DGAT1MMP8ALDH1A1POLBTSHR | |
| SCHEMBL17896932 | 0.84 | DGAT1 (0.35) | DGAT1MMP8ALDH1A1POLBTET2 | |
| SCHEMBL16368795 | 0.83 | ALDH1A1 (0.36) | DGAT1MMP8ALDH1A1TSHRHSD17B10 | |
| SCHEMBL6721877 | 0.82 | DGAT1 (0.34) | DGAT1MMP8ALDH1A1POLBCA1 | |
| SCHEMBL27871573 | 0.80 | MMP8 (0.35) | DGAT1MMP8TSHRHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170253708-A1 | WATER-SOLUBLE PACKAGING FILM | SEKISUI CHEMICAL CO., LTD. (JP) | 2017-09-07 | — | — | US | disclosed |
| US-20170247154-A1 | WATER-SOLUBLE PACKAGING FILM | SEKISUI CHEMICAL CO., LTD. (JP) | 2017-08-31 | — | — | US | disclosed |
| US-20160369072-A1 | WATER-SOLUBLE FILM FOR PACKAGING CHEMICALS AND WATER-SOLUBLE FILM PACKAGE | SEKISUI SPECIALTY CHEMICALS AMERICA, LLC | 2016-12-22 | — | — | US | disclosed |
| US-9340522-B2 | Pyrazolone-derivatives and their use as PDE-4 inhibitors | TAKEDA GMBH (DE) | 2016-05-17 | — | — | US | disclosed |
| EP-2356103-B1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | TAKEDA GMBH (DE) | 2015-08-26 | — | — | EP | disclosed |
| US-20140073672-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS | TAKEDA GMBH (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8609848-B2 | Pyrazolone-derivatives and their use as PDE-4 inhibitors | TAKEDA GMBH (DE) | 2013-12-17 | — | — | US | disclosed |
| US-20130053553-A1 | HETEROCYCLIC COMPOUNDS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2013-02-28 | — | — | US | disclosed |
| US-20110218201-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS | NYCOMED GMBH (DE) | 2011-09-08 | — | — | US | disclosed |
| EP-2356103-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PD4 INHIBITORS | Nycomed GmbH (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010055083-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PD4 INHIBITORS | NYCOMED GMBH (DE) | 2010-05-20 | — | — | WO | disclosed |
| US-20100035296-A1 | COMPOUNDS AND METHODS FOR DETECTION OF CELLS | APOSENSE LTD. (IL) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035296-A1 | COMPOUNDS AND METHODS FOR DETECTION OF CELLS | CASP3, BAX, BAD | DGAT1 552/4885MMP8 816/4885ALDH1A1 773/4885 |
| US-20130053553-A1 | HETEROCYCLIC COMPOUNDS | CYP2C8, UGT1A8, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | DGAT1 3093/4885MMP8 521/4885ALDH1A1 674/4885 |
| US-20110218201-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS | PDE4A, PDE3B, PDE3A | DGAT1 3610/4885MMP8 832/4885ALDH1A1 344/4885 |
| US-20140073672-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS | PDE4A, PDE3B, PDE3A | DGAT1 3610/4885MMP8 832/4885ALDH1A1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.