Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23318314 | 0.80 | LIPE (0.40) | MTNR1BCA12CA1CA2CA9 | |
| SCHEMBL23318319 | 0.75 | ADRB2 (0.33) | — | |
| SCHEMBL21561029 | 0.72 | RXFP1 (0.37) | KMT2AMEN1ALDH1A1LMNATP53 | |
| SCHEMBL21023276 | 0.71 | RXFP1 (0.36) | KMT2AMEN1ALDH1A1LMNATP53 | |
| SCHEMBL20808479 | 0.70 | RXFP1 (0.35) | KMT2AMEN1ALDH1A1LMNATP53 | |
| SCHEMBL20808498 | 0.70 | RXFP1 (0.35) | KMT2AMEN1ALDH1A1LMNATP53 | |
| SCHEMBL24489623 | 0.69 | FAAH (0.36) | KMT2AMEN1ALDH1A1LMNATP53 | |
| SCHEMBL21561127 | 0.69 | FAAH (0.40) | KMT2AMEN1ALDH1A1LMNATP53 | |
| SCHEMBL21948654 | 0.68 | FAAH (0.35) | KMT2AMEN1ALDH1A1LMNATP53 | |
| SCHEMBL21449893 | 0.66 | MGLL (0.46) | KMT2AALDH1A1GAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087096-A1 | P53 MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-05-06 | — | — | WO | disclosed |