Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.56 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16378745 | 0.87 | ADRA2C (0.56) | DPP4KIF11PTPN5ADRA2CRXRA | |
| SCHEMBL15863720 | 0.83 | DPP4 (0.56) | DPP4KIF11PTPN5HTR7TAAR1 | |
| SCHEMBL23995708 | 0.83 | DPP4 (0.49) | DPP4PTPN5NOS3NOS1NOS2 | |
| SCHEMBL13524539 | 0.81 | CYP1A2 (0.58) | KIF11PTPN5ALDH1A1PTAFRHTR7 | |
| SCHEMBL25094674 | 0.81 | LTA4H (0.43) | KIF11PTPN5ADRA2CRXRARXRB | |
| SCHEMBL25093374 | 0.81 | KIF11 (0.42) | KIF11PTPN5RXRARXRBNPC1 | |
| SCHEMBL25094234 | 0.78 | TACR1 (0.45) | KIF11PTPN5RXRARXRBNPC1 | |
| SCHEMBL3398445 | 0.77 | ALDH1A1 (0.52) | KIF11PTPN5RXRARXRBNPC1 | |
| SCHEMBL3787422 | 0.77 | DPP4 (0.62) | DPP4NOS3NOS1NOS2ADRA2C | |
| SCHEMBL31115680 | 0.77 | KIF11 (0.52) | KIF11PTPN5RXRARXRBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139517-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | Revolution Medicines, Inc. | 2021-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139517-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | SOST, SOS1, SOS2 | DPP4 2835/4885KIF11 4867/4885PTPN5 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.